Jul 2026· Stem Cell Reviews and Reports· Vol 22, pp. 3417 - 3438· 0 citations· 180 references
Medicine
TL;DR
Recognising the central role of VSELs/progenitors and their niche in maintaining tissue homeostasis in vivo could resolve existing roadblocks and guide more effective endogenous regenerative therapies for diseased tissues and age-related dysfunctions.
Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease.
This review discusses how organoids and OoC-based platforms are being leveraged to study and enhance cell fate reprogramming, repair, and regeneration across multiple tissues and outlines current limitations, including scalability, standardization, and biomaterial constraints.
Hrithiha Sriramulu, Hyunsung Woo, Anavi Kaul et al.· Current Opinion in Genetics...· 1 citation
A robust protocol for generating PGC-like cells (PGCLCs) from human induced pluripotent stem cells (hiPSCs) is described, starting with the initial evaluation of the pluripotent state and cellular characteristics of the hiPSCs to ensure effective PGCLC differentiation.
Elpida Konidari, M. Trimp, Carmen L. de Mooij et al.· Journal of Visualized Experi...· 0 citations
Key applications of iPSC technology in hemato-oncology are summarized, its major advantages and current limitations are discussed, and emerging directions are highlighted, including scalable iPSC-derived blood cell therapies for inherited and acquired bone marrow failure syndromes and leukemia.
Ivan Tesakov, M. Nasri, M. Klimiankou et al.· Frontiers in Immunology· 0 citations
This integrated molecular, single-nucleus, and electrophysiological characterization defines the cellular heterogeneity of DPSC-to-neuron reprogramming and provides a framework for protocol refinement and future patient-specific disease modeling.
Anna A. Abbas, Chandramouli Muralidharan, Bendegúz Sramkó et al.· bioRxiv· 0 citations
The capacity of ES cells to differentiate into almost all the cell types of human body highlights their potential to play a promising role in cell replacement therapy of human diseases.
ﻞﺸﮐ يرﺪﯿﺣ, ﺪﯿﻌﺳ· 0 citations
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