Cumulative Intraoperative Hypothermic Burden, Transfusion, and Estimated Blood Loss: A Retrospective Cohort Study

Abstract

Analysis pipeline for a retrospective cohort study of cumulative intraoperative hypothermic burden, intraoperative red cell transfusion, and estimated blood loss in 2,567 adults undergoing non-cardiac surgery, using the open VitalDB perioperative database. Scripts run in numeric order: 01-14 reproduce the originally submitted analysis, and 15-23 produce the first revision, including the edge-trimmed thermal exposure metric, threshold and dose analyses, and the table and figure builders. The repository carries code only; the manuscript, cover letters and peer-review correspondence are not distributed. VitalDB source data are openly available at https://vitaldb.net and are not redistributed here. This record accompanies the first revision submitted to BMC Anesthesiology. The archive contains the repository in full: scripts/, README.md, requirements.txt, .zenodo.json and .gitignore. Method note. Core temperature was previously integrated across the whole anaesthesia window, which counts probe equilibration at insertion and probe withdrawal at emergence as hypothermia, implying an implausible cohort nadir of 33.30 °C. Exposures are now computed after excluding the first and last 5 minutes of each case's monitored window. Cumulative burden is essentially unchanged (Pearson r=1.00, Spearman rho=0.99); the nadir corrects to 35.04 °C. Scripts run in numeric order. 01-14 reproduce the originally submitted analysis; 15-22 produce the revision. The manuscript, cover letters and peer-review correspondence are not part of this distribution. VitalDB source data are openly available at https://vitaldb.net and are not redistributed here.