Cumulative Intraoperative Hypothermic Burden, Transfusion, and Estimated Blood Loss: A Retrospective Cohort Study

Abstract

Superseded. This record is retired and should not be used or cited. It is replaced by 10.5281/zenodo.22234051, which is the archive accompanying the manuscript. Version v2.0.0 of this record (10.5281/zenodo.22232689) additionally contained files that should not have been distributed and its removal has been requested. Analysis pipeline for a retrospective cohort study of cumulative intraoperative hypothermic burden, intraoperative red cell transfusion, and estimated blood loss in 2,567 adults undergoing non-cardiac surgery, using the open VitalDB perioperative database. Scripts run in numeric order: 01-14 reproduce the originally submitted analysis, and 15-23 produce the first revision, including the edge-trimmed thermal exposure metric, threshold and dose analyses, and the table and figure builders. The repository carries code only; the manuscript, cover letters and peer-review correspondence are not distributed. VitalDB source data are openly available at https://vitaldb.net and are not redistributed here. v2.2.0 is the clean release accompanying the first revision submitted to BMC Anesthesiology. The repository was rebuilt from a single commit containing code only. Key methodological change from v1.1.0: core temperature had been integrated across the whole anaesthesia window, which counts probe equilibration at insertion and probe withdrawal at emergence as hypothermia, implying an implausible cohort nadir of 33.30 °C. Exposures are now computed after excluding the first and last 5 minutes of each case's monitored window. Cumulative burden is essentially unchanged (Pearson r=1.00, Spearman rho=0.99); the nadir corrects to 35.04 °C. Earlier v2.x versions are superseded. v2.0.0 in particular should not be used.