This review critically evaluates whether MAM-related mechanisms contribute to asthma pathogenesis and where the current evidence remains indirect, and distinguishes MAM-specific mechanisms from MAM-adjacent ER or mitochondrial stress responses across different asthma-relevant cell types.
This review delineates how the canonical UPR sensors transduce metabolic stress into pro-inflammatory signaling cascades and discusses the organ-specific consequences of ERS in the liver, pancreas, adipose tissue, vascular endothelium, and hypothalamus, highlighting how this stress sustains a self-reinforcing cycle of...
B. Wen, Xiaojin Wu, Kaiying Zhang et al.· Pharmacological Research· 0 citations
Current evidence linking mitochondrial dysfunction, ER stress, and ER-mitochondrial crosstalk to the pathogenesis of chronic pain is summarized and their potentials as therapeutic targets are discussed.
A. Yadawa, Su-Fang Liu, F. Tao· Brain Science· 0 citations
This framework separates association, susceptibility, execution, inflammatory release, tissue consequence, and therapeutic relevance when interpreting links among metabolic stress, mitochondrial stress, and RCD in sepsis.
Guohairong Pan, Lulu Zhou, Ruochong Wang et al.· Journal of Inflammation Rese...· 0 citations
This paper systematically summarizes the molecular mechanisms by which mitochondria mediate apoptosis and provides an in‐depth analysis of intrinsic factors, including mitochondrial structural remodeling, dynamics imbalance, dynamics imbalance, and mitochondrial DNA abnormalities.
Ru-Bin Tan, Jin-Ming Zhao, Rong Wang et al.· MedComm· 0 citations
This review summarizes the key receptors, regulatory mechanisms, and the latest research on ER-phagy in various inflammation-related diseases, aiming to draw academic attention to the important value of ER-phagy in inflammatory diseases.
Chunxia Wang, Jing Gao, Changsheng Guo et al.· Frontiers in Immunology· 0 citations
Although mtISR has been characterized in primary mitochondrial myopathies, secondary mitochondrial dysfunction in neuromuscular disorders suggests that mtISR-related pathways may also be activated in these conditions, and its roles in skeletal muscle pathology are discussed.
İsra Şinik, Evrim Aksu-Mengeş, B. Balci-Hayta· Bratislava Medical Journal· 0 citations
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