TL;DR
In insights on the research regarding therapeutic approaches of NDs which intend to target molecular components, a general understanding of proteostasis, ER stress, UPR signalling and how these cellular processes are related to neurodegeneration is provided.
Overexpression of Rpt3 enhanced proteasome assembly and activity, reducing intracellular ubiquitin levels in hac1Δ, and upregulates Hac1 protein abundance, thereby ensuring proteostasis maintenance.
Evidence is synthesized that ER stress is not merely a correlation of aging but a mechanistic contributor to age-related decline, with senescence emerging as a major downstream fate in multiple tissues and therapeutic opportunities and open questions centered on restoring adaptive PERK/ISR dynamics to support healthy a...
This review systematically elaborates on the key pathological roles and molecular mechanisms of ERS and the triggered UPR in Parkinson's disease and discusses various intervention approaches, their research progress, and associated challenges.
This review summarizes the key receptors, regulatory mechanisms, and the latest research on ER-phagy in various inflammation-related diseases, aiming to draw academic attention to the important value of ER-phagy in inflammatory diseases.
The role of the UPS in glial cells in various neurodegenerative diseases is reviewed, and how studying glial cell function might provide essential information in unraveling mechanisms of neurodegenerative diseases is discussed.
This review summarizes recent advances in understanding the molecular factors that regulate SG assembly and disassembly, as well as the pathological processes that drive the conversion of SGs into aggregates associated with neurodegenerative diseases and discusses the therapeutic potential of targeting these pathways t...
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