TL;DR
Findings suggest that AhpC1 functions alongside catalase systems in the oxidative stress defense network of V. parahaemolyticus.
Vibrio anguillarum is a major bacterial pathogen in marine aquaculture, which causes significant economic losses. The histone-like protein HU, a conserved nucleoid-associated protein, plays crucial roles in chromosome organization, global gene regulation, and stress adaptation. In many bacteria, HU exists as both a hom...
Transcriptional analysis revealed that compared to neutral conditions, osmotic stress-related genes were significantly upregulated in the ΔliaS strain under acidic conditions, indicating that LiaS modulates acid tolerance through transcriptional regulation.
The results show that although hydrogen peroxide and paraquat induce msrA/B expression, the ΔmsrA/B strain was not susceptible to either oxidant, whereas the ΔclpX strain was sensitive to both.
A novel role is identified for FlhF, a GTPase essential for proper flagellar assembly, in promoting resistance to hydrogen peroxide (H2O2) in C. jejuni, offering new insights into flagella-associated defense mechanisms in this pathogen.
ABSTRACT This study used a functional genomics approach to explore the role of a xenobiotic response element (XRE)-type regulator (SMU.405c) in Streptococcus mutans physiology, including the expression of biofilm regulatory protein BrpA. Results showed that deletional mutation of xre significantly reduced the ability o...
Results demonstrate that PlsC is essential for maintaining membrane homeostasis and stress resistance in Brucella, which in turn supports its survival within professional phagocytes and full virulence in vivo and suggests a critical link between phospholipid metabolism and Brucella pathogenicity.
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