Cell-Based Sensor for Extracellular DNA

Co-Localization-Gated Multivalent DNA Logic Gate for Programmable Cell Recognition.

This work presents a programmable molecular device that integrates Boolean logic computation with spatial confinement to overcome limitations in affinity, specificity, and off-target binding, and demonstrates a strategy for programming high-fidelity molecular interactions on interested cell surfaces.

A Programmable DNA Biohybrid Material Coupled with Intelligent Cell-Free Computation for Environmental Sensing

Programmable materials integrated with intelligent signal processing are essential for developing adaptive and autonomous environmental sensing systems. Here, we present a biohybrid material platform in which environmental DNA is captured by streptavidin (SA)-functionalized microparticles and delivered to a cell-free t...

Revealing the Regulatory Interplay of NHE1 mRNA and Na+ in Cancer Cells Using a DNA Nanosensor.

Two orthogonal gold-nanoparticle-based DNA nanosensors that enable simultaneous imaging of sodium/hydrogen exchanger 1 (NHE1) mRNA and Na+ dynamics in hepatocellular carcinoma cells are reported, providing a molecular tool for decoding ion-based signaling networks in cancer biology.

A dual-recognition fluorescence chip utilizing a substrate-borne DNA walker for precision profiling of small extracellular vesicles.

A fluorescence chip based on a membrane-anchored, bipedal DNAzyme walker assembled on small extracellular vesicles (sEVs) surfaces via catalytic hairpin assembly (CHA) opens a new paradigm for designing efficient DNA nanomachines on membrane-enveloped targets.

Membrane-anchored DNA nanodevice with allosteric aptamer arms enables parallel probing and on-site drug delivery

A DNA nanodevice that anchors to cell membranes and releases chemotherapy only when three specific cancer markers are detected simultaneously is developed, establishing a versatile platform for logic‑controlled, multimarker‑guided cancer theranostics.

DNAzyme-mediated fluorescence sensor based on covalent organic framework for Pb2+ detection