Remnant cholesterol inflammation index (RCII) as a potential biomarker for ACPA-negative rheumatoid arthritis: evidence from dual-cohort analysis and serum lipidomics.

Yuan-Yuan Liu Xiao-Ming Wang Zi-Xin Zang Yao Yao Yu-dong Liu S. Lam Ju Cui Xuan Zhang Min Wang

Aug 2026 · Clinical Rheumatology · 0 citations · 24 references

Medicine

TL;DR

Elevated RCII levels were significantly elevated in ACPA-negative RA, ACPA-positive RA, undifferentiated inflammatory arthritis, dermatomyositis, and systemic lupus erythematosus compared with HCs, with the highest levels observed in ACPA-negative RA.

DOI PubMed Semantic Scholar

View source

Similar papers

Review Jul 2026

Residual Cholesterol Inflammatory Index: A Predictor of Cardiovascular-Kidney-Metabolic Syndrome; Insights from NHANES and CHARLS Cohorts.

RCII exhibited an independent and positive association with CKM risk in the US and Chinese populations, with consistent dose-response and nonlinear trends, and may be a practical and integrative biomarker for identifying individuals with an increased CKM risk.

Mengchen Zhang, Linlin Huang, Tian Zhang et al. · Anatolian journal of cardiol... · 0 citations

Open access Jul 2026

Higher remnant cholesterol inflammatory index is associated with increased frailty risk in the UK Biobank

Higher RCII levels, both at baseline and cumulatively, are associated with an increased risk of frailty, and this biomarker may be a promising biomarker for frailty risk stratification and a potential target for early prevention in aging populations.

Qianyu Zhou, Mengting Liu, Lianke Wang et al. · Frontiers in Nutrition · 0 citations

Open access Aug 2026

Disease-specific biomarker value of C-reactive protein and its composite indices in autoinflammatory diseases: an integrated study of multi-modal omics and population cohorts

Serum CRP levels showed a disease specific distribution across AIDs, with the highest levels in hyperinflammatory conditions such as AOSD and MAS, suggesting their potential as disease-specific biomarkers.

Qian-Yue Yang, Yu-Lu Zhang, Xiaomin Li et al. · Frontiers in Immunology · 0 citations

Aug 2026

Pan-immune-inflammation value is associated with thyroid autoantibody positivity in a Chinese health examination cohort

Elevated PIV is non-linearly associated with thyroid autoantibody positivity, particularly TgAb, with stronger effects observed in women and hypertensive individuals, with stronger effects observed in women and hypertensive individuals.

Yunzhi Chen, Jialin Liao, W. Feng et al. · Endocrine · 0 citations

Jul 2026

Evidence from two large prospective cohorts: variations in remnant cholesterol inflammation index and the risk of cardiometabolic multimorbidity in middle-aged and elderly populations.

By integrating lipid and inflammatory pathways, the RCII was significantly associated with incident CMM and may enhance early risk stratification and may enhance early risk stratification.

Song Wen, Zhonghua Sun, Yanjun Song et al. · Diabetes Research and Clinic... · 0 citations

Open access Jul 2026

Dual residual risk of lipid and inflammation: a prospective analysis of RCII on hypertension incidence and cardiovascular prognosis in Chinese and UK populations.

Findings support RCII as a complementary lipid-inflammatory residual-risk marker; however, external validation and decision-utility studies are needed before clinical implementation.

Lerui Wang, Si-Yuan Wen, Zhiyi Ma et al. · BMC Cardiovascular Disorders · 0 citations