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Jul 2026

Relationship between BDNF rs6265 (VAL66MET) polymorphism and serum BDNF LEVELS in anxiety disorders

It is demonstrated that decreased serum BDNF levels are associated with the presence and symptom severity of anxiety disorders, and the Val66Met polymorphism does not appear to be a primary determinant of serum BDNF levels in this population, suggesting that other genetic or environmental factors may be involved.

Dicle Yilmaz Uyanik, Merve Şahin Can, O. Baykan et al. · 0 citations
Jul 2026

Association of BDNF Val66Met polymorphism with clinical severity, cognitive function, and treatment response in schizophrenia

BDNF Val66Met polymorphism was significantly associated with clinical symptom severity, cognitive function, and treatment-related improvement among Acehnese individuals with schizophrenia, and the Val/Val genotype was associated with a more favorable clinical and cognitive profile and stronger early clinical and cognit...

Juwita Saragih, Irwan Saputra, Marty Mawarpury et al. · 0 citations
Open access Jul 2026

Serotonin transporter polymorphism (5-HTTLPR) is associated with post-awakening cortisol measures in previous depression

It is suggested that 5-HTTLPR-related differences, when present, may be more detectable in overall post-awakening cortisol output than in baseline-relative increase, which is more detectable in overall post-awakening cortisol output than in baseline-relative increase.

R. Jonassen, Ø. Øverli, E. Hilland et al. · 0 citations
Open access Aug 2026

Associations between high perceived stress, inflammatory proteins, and BDNF: a cross-sectional study of young adult females in Shanghai, China.

Findings indicated that Chinese, young women with HS exhibit distinct inflammatory profiles and reduced BDNF levels, suggesting that chronic stress may be associated with increased inflammation and compromised neuronal plasticity, highlighting the need for future longitudinal studies to clarify the long-term impact of...

Ping Gao, Hong Zhang, Xue Xiao et al. · 0 citations
Open access Aug 2026

Is Stress Reactivity an Intermediary Mechanism in the Association Between NR3C1 Methylation and Adolescent Loneliness?

This study examined whether saliva-derived DNA methylation in the glucocorticoid receptor (NR3C1) gene was linked to loneliness through dysregulation of the hypothalamic-pituitary-adrenal axis (HPA-axis) in 101 early adolescents (Mage = 11.61 years, SDage = 0.64, 55.45% girls). Using person-centered analyses to account...

Yentl Koopmans, S. Nelemans, Patricia Bijttebier et al. · 0 citations
Open access Aug 2026

Anxiety and Depression Traits Are Moderated by a Sex-Dependent Genetic Interaction Between 5-HTTLPR and BDNF

The findings reveal a complex, sex-dependent genetic interaction that selectively influences anhedonia and anxiety, which highlights the value of considering sex-stratified genetic backgrounds and symptom specificity to advance personalised precision medicine in psychiatry.

G. L. Odierna, C. Sharpley, V. Bitsika · 0 citations

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