Skip to content
Log in
Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Identification of novel loci regulating circulating melatonin and its causal relationship with hypertension

Lin Yan Yang Qiu Zhi-Wen Mo Mingli Li Xu-dong Huang Yongfen Gao Bo-Teng Yan Qiantu Hu Haiying Zhang Zengnan Mo Rui Lin
Aug 2026 · Human Genetics · Vol 145 · 0 citations · 71 references
Medicine

TL;DR

Findings reveal novel genetic contributors to melatonin regulation and establish their putative causal relationship with hypertension.

DOI PubMed Semantic Scholar
View source

Similar papers

Open access Aug 2026

Identifying causal genetic variants for high-altitude adaptation through blood eQTL analysis in plateau populations

This study offers a comprehensive eQTL map and reveals causal chains of “variant-gene-phenotype” for HAA-related traits, which provides new insights into potential regulatory mechanisms and targets for prevention and treatment of altitude sickness.

Chenghui Zhao, Jia-Wei Guan, Jun-Hua Liu et al. · 0 citations
Review Jul 2026

Genetic evidence for a causal relationship between melatonin metabolism and depression.

To investigate the causal relevance of melatonin metabolism, which provides the biological basis for circulating melatonin levels, to specific depression symptom subtypes, we performed a targeted systematic review of melatonin metabolism pathways in the human brain and liver. Using two-sample Mendelian randomization (M...

Yuan-Bi Wang, Wen Wen, Han-Sheng Chen et al. · 0 citations
Open access Aug 2026

Multi-omic characterization of the Hispanic/Latino blood lipidome reveals an additional locus and attenuated genetic prediction.

A lipidome-wide GWAS of 830 lipid species in 2,287 Hispanic/Latino participants and predictive modeling across omics layers provided a genetic landscape of lipid metabolism in a highly burdened population and highlights the challenges in predicting lipid abundance.

Wanying Zhu, Hung-Hsin Chen, H. Highland et al. · 0 citations
Open access Aug 2026

A Functional SNP in the Promoter Region of Ovine IDO2 Associated With Melatonin Levels via Affecting Transcription Activity by CLOCK.

Findings suggest that the g.-809C allele decreases IDO2 transcription by reducing CLOCK binding affinity, thereby potentially affecting IDO2-associated tryptophan/melatonin metabolism and increasing melatonin levels, which may contribute to photoperiodic responses in sheep.

Xunping Jiang, Shaxuan Chi, Xiaodong Wang et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.