This review critically examines bacteriophage-based antimicrobials, CRISPR-Cas therapeutic systems, and their emerging integration as CRISPR-armed phages, highlighting their comparative advantages, current limitations, and future potential as promising targeted antimicrobial approach platforms requiring further clinical validation.
A systematic overview of bacteriophage biology, life cycle, and mechanisms of action is provided, highlighting the influence of phage morphology on therapeutic performance, recent advances, current clinical and preclinical studies, and future perspectives.
Rika Rani Pradhan, Sanghamitra Pati, S. K. Samal· International journal of pha...· 0 citations
This study investigates the CRISPR-Cas framework’s potential as a cutting-edge tactic to fight antimicrobial resistance, and finds that the efficiency of CRISPR-Cas is diminished in some bacterial strains due to variations in their CRISPR loci.
Akmal Zubair, M. Hemal, Alaeldeen Ahmed et al.· Archives of Microbiology· 0 citations
The increasing clinical evidence shows that synthetic biology can effectively overcome the inherent defects of natural bacteriophages, confirming the safety and initial efficacy of bacteriophage therapy.
Xuan Wang, Haolin Zhou, T. S. Lim et al.· International Journal of Mol...· 0 citations
Overall, CRISPR-based antimicrobial therapy represents a transformative approach to precision infectious disease management, with continued technological innovation, interdisciplinary collaboration, and robust clinical validation expected to facilitate its safe, effective, and clinically accessible implementation again...
Dipankar Mukhopadhyay, Dr. Shilanjali Bhalerao, Dr. Vijayendra Gautam et al.· Genetics and Molecular Resea...· 0 citations
Accumulating experimental and clinical evidence indicates that bacteriophage therapy could become an important component of future antimicrobial strategies, and Continued multidisciplinary research, standardized clinical protocols, and well-designed randomized clinical trials are essential to establish its long-term ef...
Himadri Sharma· International Journal of Res...· 0 citations
Chickpea proteins, especially the basic subunit (BS) fraction, demonstrated significant antibacterial activity against MDR pathogens, offering a promising natural alternative to conventional antibiotics.
Reham Sobhy, H. El-Beltagi, Othman M. Al-Dossary et al.· Journal of King Saud Univers...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.