Rapid Detection and Initial Treatment of Life-Threatening Subdural Hematoma in a Sheep Model

Abstract

Traumatic brain injury (TBI) is the leading cause of death and disability in people under 40 worldwide. There is an unmet need for detection and treatment of life-threatening TBI when computed tomography (CT) scanners and neurosurgeons are unavailable. We developed a new handheld frequency-domain multidetector infrared hemorrhage detection device. Using the new device, military pre-hospital medics required <4 minutes to detect life-threatening subdural hematoma in a sheep model. We developed a second device that allows non-neurosurgeons to safely create a burr hole and partially remove clotted subdural blood. In sheep, the treatment device reduced intracranial pressure within 20 minutes, and improved post-anesthesia blinded neurological outcomes. With human use adaptation, these devices could allow rapid detection and initial treatment of some life-threatening TBIs in challenging situations.