Block Versus Particulate Deproteinized Bovine Bone Mineral for Guided Bone Regeneration of Peri-Implant Dehiscence Defects: A 5-Year Randomized Controlled Trial.

Efficacy of injectable platelet-rich fibrin associated with particulated deproteinized bovine bone mineral in horizontal maxillary regeneration – a randomized, triple blinded, split-mouth controlled clinical trial

Demineralized bone allograft fibers versus particulate in sinus augmentation: A double-arm randomized controlled and histomorphometric study.

BACKGROUND The primary aim of this study was to evaluate histologic wound healing of demineralized freeze-dried bone allograft (DFDBA), in particulate (P) or fiber (F) form, in combination with deproteinized bovine bone mineral (DBBM) for maxillary sinus floor augmentation. Two stains were used to evaluate whether the type of stain had an effect on histologic analysis. METHODS This two-arm, parallel, randomized controlled trial included 29 patients with maxillary posterior edentulism requiring maxillary sinus augmentation to facilitate implant placement. Patients were blindly randomized into one of two groups: DBBM+F or DBBM+P. After 6 months of healing, bone cores were collected for histologic evaluation of vital bone, residual allograft, residual xenograft, and connective tissue (CT)/other using two stains (hematoxylin and eosin [H&E] and Masson's trichrome). RESULTS No statistically significant differences were observed between the DBBM+F and DBBM+P groups for percent vital bone formation, residual graft, or CT/other on mixed linear model analysis (all p > 0.05). Paired analysis demonstrated no statistically significant differences between H&E and trichrome staining for percent vital bone formation, residual allograft, or residual xenograft (all p > 0.05). However, a statistically significant difference was observed for CT/other, with trichrome staining yielding lower mean values than H&E (mean paired difference -8.03%, p = 0.0146). CONCLUSION Both graft combinations demonstrated comparable histomorphometric outcomes within the limits of this study. Masson's Trichrome staining may improve discrimination between osteoid/collagen matrix and mineralized tissue interfaces during histomorphometric analysis.

Membrane-free guided tissue regeneration with enamel matrix derivative and bone graft materials improves 3-dimensional periodontal outcomes in small dogs.

Objective To evaluate the clinical and radiographic outcomes of membrane-free guided tissue regeneration (GTR) using enamel matrix derivative (EMD) with bone grafts in dogs with vertical infrabony periodontal defects. Methods This retrospective study reviewed cases of client-owned dogs that underwent membrane-free GTR using EMD in combination with bone grafts between August 1, 2023, and September 30, 2025. Outcomes were assessed from records and cone-beam computed tomography (CBCT) datasets using 2-D measurements of clinical attachment loss (CAL) and vertical bone defect ratio (VBDR) and 3-D volumetric analysis. Success was defined as CAL improvement (≥ 1 mm) and VBDR reduction (> 10%). Volumetric analysis was used to quantify infrabony defect fill. Results 20 periodontal defects in 16 dogs were included (allograft, n = 10; xenograft, 10). Median follow-up was 7 months (range, 6 to 14 months). All defects met the success criteria. Median CAL decreased from 5.0 mm (range, 3.0 to 8.0 mm) to 2.0 mm (range, 1.0 to 3.0 mm), and median VBDR decreased from 0.42 (range, 0.16 to 0.78) to 0.18 (range, 0.04 to 0.46). Volumetric analysis revealed a median infrabony defect fill of 98.49% (range, 71.86% to 100.00%). Conclusions Membrane-free GTR with EMD was associated with clinically meaningful periodontal improvement and substantial infrabony defect fill in appropriately selected canine patients with vertical infrabony defects. Prospective, controlled studies are warranted to further evaluate its efficacy and indications. Clinical Relevance This membrane-free regenerative approach may provide a practical tooth-preserving treatment option for selected small-breed dogs when conventional barrier-membrane placement is technically challenging.

Comparative Evaluation of Bone Ring versus Particulate Bone Graft using CBCT in Buccal Bone Augmentation with Simultaneous Implant Placement: A Randomised Controlled Trial

The Bone Ring Technique (BRT) is a newer viable option for restoring complex defects around dental implants with three-dimensional bone augmentation with significant height and width augmentation of buccal bone.

Surgical Therapy for Peri-Implantitis Using Deproteinised Bovine Bone Mineral With 10% Collagen, Enamel Matrix Derivative and Doxycycline: A Prospective Cohort 10-Year Implant Study.

AIM To assess 10-year implant survival following surgical management of peri-implantitis using deproteinised bovine bone mineral with 10% collagen (DBBMC), enamel matrix derivative (EMD) and doxycycline powder. MATERIALS AND METHODS The original population comprised 30 non-smoking, periodontally stable patients (mean age = 44.9 ± 11 years; 64% female; full-mouth plaque and bleeding score < 20%, no bleeding residual periodontal pockets ≥ 4 mm), each with a single peri-implantitis-affected implant (bleeding on probing, probing depth > 6 mm, ≥ 20% radiographic bone loss, implants in function ≥ 2 years). The surgical procedure involved implant surface decontamination with 24% EDTA followed by defect fill with DBBMC/EMD/doxycycline mixture. Patients underwent individualised supportive peri-implant therapy (SPIT) comprising regular clinical monitoring, professional cleaning and antimicrobial protocols for 10 years. RESULTS Twenty-nine of the 30 implants survived (96.6% survival rate). Mean probing depth decreased from 8.90 ± 1.9 mm to 3.06 ± 0.98 mm; radiographic bone loss improved from 57% ± 16.5% to 13% ± 2.5%. During 10-year SPIT, 12 implants required adjunctive azithromycin. Fifty-eight percent achieved the successful treatment outcome criterion (SOTC: probing depth < 5 mm, no bone loss 10% from baseline, absence of bleeding on probing/suppuration and recession < 0.5 mm anterior/1.5 mm posterior implants). CONCLUSION Surgical management of peri-implantitis combined with DBBMC/EMD/doxycycline and personalised SPIT achieved high long-term implant survival and stable clinical outcomes over 10 years.

Guided Bone Regeneration for Vertical Alveolar Augmentation: Clinical Evaluation of d-PTFE-Ti Membranes and Comparison with Collagen Membranes: A Systematic Review

Based on the growing use of guided bone regeneration (GBR) for implant rehabilitation in atrophic alveolar ridges, the choice of barrier membrane remains a critical factor for clinical success. This review aimed to evaluate the clinical effectiveness of titanium-reinforced dense polytetrafluoroethylene (d-PTFE-Ti) membranes compared with resorbable collagen membranes in vertical ridge augmentation. A literature review was conducted using PubMed, Cochrane Library, and ScienceDirect databases. Clinical studies published since 2014 involving human subjects undergoing GBR procedures with either d-PTFE-Ti or collagen membranes were included. Nine studies met the inclusion criteria, including randomized clinical trials and cohort studies. The selected studies indicated that both membrane-based approaches were effective in promoting bone regeneration and enabling implant placement. Titanium-reinforced d-PTFE membranes may offer mechanical advantages in space maintenance and dimensional stability, particularly in larger vertical defects; however, the available comparative evidence did not demonstrate a consistent statistically significant superiority over collagen-based approaches. Within the limitations of the available evidence, both strategies appear to provide clinically predictable outcomes, and membrane selection should be individualized according to defect morphology and treatment requirements.