Jul 2026· International Journal of Pharmaceutical Quality Assurance· Vol 16· 0 citations· 19 references
TL;DR
Early-stage tumors, smaller size, absence of’ nodal involvement, and non-aggressive histology are associated with favorable outcomes and a risk-stratified treatment approach—primarily total thyroidectomy with selective lymph node dissection and appropriate adjuvant ‘ therapy—remains essential for optimizing long-term disease control.
Abstract
Background: Thyroid carcinoma is the most common endocrine malignancy, exhibiting diverse histopathological
patterns and variable prognostic outcomes. Early detection and ‘
risk-adapted management are essential to optimize
long-term survival.
Aim: To evaluate the management strategies, associated complications, and prognostic determinants in patients
with thyroid carcinoma.
Methodology: A hospital-based observational analytical study was conducted in the Department of General
Surgery, IGIMS, Patna, including 90 histopathologically confirmed cases of ‘
thyroid carcinoma. Data on
demographics, tumor characteristics, surgical and adjuvant treatment, complications, recurrence, and survival
were analyzed.
Results: Most patients were middle-aged (31–50 years, 38.9%) with a slight male predominance (55.6%).
Papillary carcinoma was the most common type (66.7%), and 44.4% were diagnosed at Stage I. Total
thyroidectomy (61.1%) followed by thyroxine suppression therapy (77.8%) was the principal management
approach. Postoperative complications were infrequent, with hypocalcemia being the most common (16.7%).
Tumor size >2 cm, lymph node involvement, and aggressive histopathological variants were identified as major
prognostic determinants. The overall recurrence rate was 10%, while 1-year and 3-year survival rates were 85%
and 75%, respectively.
Conclusion: Early-stage tumors, smaller size, absence of’ nodal involvement, and non-aggressive histology are
associated with favorable outcomes. A risk-stratified treatment approach—primarily total thyroidectomy with
selective lymph node dissection and appropriate adjuvant ‘
therapy—remains essential for optimizing long-term
disease control.
Pat age, lymph node metastases, capsular invasion, and tumor size were the most important prognostic factors in relation to recurrence rate, while the roles of tumor multifocality and lymphovascular invasion were insignificant.
S. Ibrahim, A. A. Mohammed, Mohammed Naguib Mohamed et al.· The Egyptian Journal of Otol...· 0 citations
Introduction: Differentiated thyroid cancer (DTC) accounts for the most common types of thyroid cancer. The aim of the present study was to investigate the factors associated with recurrence and mortality after thyroidectomy in patients with diagnose of DTC in Hamadan, Iran. Materials and Methods: In this retrospective cohort study, 350 patients over 18 years old who underwent total thyroidectomy and ablation with radioactive iodine (RAI) and had DTC based on pathology and followed up for ten years were studied. The univariate and multivariate logistic regression was used for determining the risk factors of recurrence and mortality of DTC at a significance level of 0.05. SPSS software (Version 26) was applied to analyze the data. Results: In the present study, 16.6% of the participants were male and 83.4% were female with a mean age of 40.7 ±14.7 years. Recurrence and mortality rates were obtained to be 26.9% and 4.9 %, respectively. Overall, the risk of recurrence and death was significantly higher in older age, men, smokers, tumors larger than 4 cm and regional lymph node (p<0.05). For each additional year of life, the risk of recurrence and death increased by 4% and 9%, respectively (P =0.001 and p<0.001). Recurrence in men were 5.111 times more likely than women (p<0.001). A 6.002-fold increase in the risk of death was associated with smoking (P=0.008). Conclusion: Due to the high prevalence of DTC and on the other hand the good prognosis of this type of cancer, timely diagnosis and identification of risk factors of recurrence and death are very important.
Background: Thyroid disease is a common indication for surgery, and histopathology remains the definitive method for diagnosis. This study described the pattern of thyroid diseases.
Methods: retrospective descriptive-analytical study was conducted in three main hospitals of Taiz City Al-Dakaf, Al-Gomhouri Teaching and Al-Safwa) covering January 2023 to December 2024. Records of 250 patients who underwent thyroidectomy
Results: Females comprised 92.4% of patients, with a median age of 40 years. Multinodular goiter was the most frequent benign lesion (46.0%) while malignancy was identified in 39 patients (15.6%), papillary-patterned carcinoma accounted for 92.3% of malignant tumors. Hoarseness, weight loss, appetite loss, cervical lymphadenopathy, suspicious ultrasound and FNA findings, higher TI-RADS categories
Conclusion: Approximately one in six thyroidectomy specimens was malignant. Clinical warning symptoms combined with ultrasound findings improved preoperative risk stratification and may support earlier diagnosis and appropriate surgical management in resource-limited settings.
Background/Objectives: Uterine adenosarcoma is a rare uterine malignancy with limited evidence on prognostic factors and long-term outcomes. We aimed to evaluate clinicopathological characteristics, treatment patterns, oncologic outcomes, and prognostic factors associated with disease-free survival (DFS) and overall survival (OS) in patients with uterine adenosarcoma. Methods: This multicenter retrospective cohort study included 43 patients with histopathologically confirmed uterine adenosarcoma who underwent primary surgery at seven tertiary referral centers in Türkiye between 2016 and 2026. Clinicopathological features, treatment modalities, recurrence patterns, and survival outcomes were assessed. Survival was analyzed using Kaplan–Meier and log-rank methods, and multivariable Cox proportional hazards regression was performed to identify independent prognostic factors. Results: The mean age at diagnosis was 59.1 ± 10.8 years, and 83.7% of patients were postmenopausal. Pelvic pain (62.8%) and abnormal uterine bleeding (60.5%) were the most common presenting symptoms. Most patients (79.1%) underwent laparotomy, and 79.1% had stage I disease. Sarcomatous overgrowth (SO) was present in 44.1% and lymphovascular space invasion (LVSI) in 18.6%. During a median follow-up of 72 months, 34.9% experienced recurrence, most commonly in the pelvis. The five-year DFS and OS rates were 59.9% and 80.4%, respectively. SO was independently associated with DFS (HR 4.41, 95% CI 1.21–16.08; p = 0.025) and OS (HR 10.23, 95% CI 1.16–89.80; p = 0.036), while LVSI was independently associated with OS (HR 11.17, 95% CI 1.34–93.14; p = 0.026). Conclusions: Uterine adenosarcoma showed favorable long-term survival but substantial recurrence risk. SO and LVSI may have potential prognostic relevance and could contribute to postoperative risk assessment and individualized follow-up.
Atacem Mert Aytekin, I. B. Ozcivit Erkan, Seyma Okumus et al.· Cancers· 0 citations
The findings highlight the importance of early detection, timely surgical intervention, and multimodal adjuvant therapy in improving outcomes among breast carcinoma patients.
Siddharth Shukla, Y. Shukla, Krishnanand et al.· Asian Journal of Medical Res...· 0 citations
Introduction: Gallbladder cancer (GBC) is a rare but highly lethal malignancy with significant variability in mortality based on demographic and clinical factors. This study aims to analyze the impact of gender, age, tumor stage, and treatment modalities on mortality in GBC patients, providing a comprehensive overview of the factors influencing survival outcomes.
Methods: We conducted a retrospective analysis of 1,527 patients diagnosed with GBC between 2005 and 2021. Data were collected on demographic variables, tumor stage, treatment modalities (chemotherapy, surgery, radiation), and survival outcomes. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HRs) for overall and cancer-related mortality, adjusting for potential confounders.
Results: The study cohort comprised 1,527 patients, predominantly female (68.11%), with most patients diagnosed between ages 60 and 79 years (56.65%). The majority were married (59.66%), and most tumors were at a regional stage (65.49%) at diagnosis. Non-Hispanic whites were the largest racial group (50.03%), followed by Hispanics (23.51%). A significant proportion of patients resided in metropolitan areas (60.64%) and had annual incomes between $60,000 and $79,999 (41.00%). High rates of radiation (85.46%) and chemotherapy (76.03%) were observed, with 81.34% undergoing surgery.
Multivariate analysis revealed that male gender was associated with a higher overall mortality risk (HR=1.19, 95% CI 1.05-1.36, p
Conclusion: Our study underscores the critical role of demographic and clinical factors in influencing GBC outcomes. Male gender, older age, and distant tumor stage are significant predictors of higher mortality, while chemotherapy and surgery substantially improve survival. The findings highlight the necessity for targeted interventions and personalized treatment approaches to enhance survival rates in GBC patients, taking into account these key prognostic factors. Further research is warranted to explore the nuanced effects of racial and ethnic disparities in GBC outcomes.
Ayrton I. Bangolo, Behzad Amoozgar, B. Alqinai et al.· Journal of Community Hospita...· 0 citations
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