Early life stress (ELS) in the form of adverse experiences in childhood results in multiple psycho-physiological pathologies during adulthood and accelerates aging. Such pathologies are recently observed to be alleviated upon nicotinamide treatment in a maternal separation model of ELS. We report a nicotinamide-driven amelioration of gut dysbiosis in middle-aged rodents with a history of neonatal maternal separation.
Stuti Srivastav, Pratik R. Chaudhari, Shital Suryavanshi et al.· bioRxiv· 0 citations
Connections between chronic stress, inflammation, and human diseases are well-established but poorly understood. In this issue of Cell Genomics, the effects of stress hormones on the immune system are investigated using single-cell RNA sequencing to better understand how stress-regulated immunological signaling contributes to disease.
Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction.
Yuanyuan Li, Jingwei Mao, Yiwen Deng et al.· Immunity, Inflammation and D...· 0 citations
Wang et al. identify a gut-brain pathway in which loss of the commensal bacterium Alistipes shahii reduces indole production, prevents hippocampal indole-AhR signaling, and drives anxiety and depression behaviors in patients and mouse models of irritable bowel syndrome.1.
Depressive disorder is commonly associated with gastrointestinal dysfunction, but the specific cellular and molecular alterations within the colonic mucosa remain poorly understood. The role of stromal–epithelial crosstalk in the colonic niche under depressive conditions is particularly unclear.
Xiao-Song Xu, Wan-Ning Zhang, Xu-Rui Hao et al.· Brain and Behavior· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.