Oct 2026· International journal of urology· Vol 33· 0 citations· 15 references
Medicine
TL;DR
Enfortumab vedotin plus pembrolizumab (EV) plus pembrolizumab (EVP) has become a standard first‐line regimen for unresectable locally advanced or metastatic urothelial carcinoma.
Abstract
Enfortumab vedotin (EV) plus pembrolizumab (EVP) has become a standard first‐line regimen for unresectable locally advanced or metastatic urothelial carcinoma. Further characterization of clinical heterogeneity and toxicity may complement existing Japanese real‐world data.
Perioperative treatment with enfortumab vedotin (EV) plus pembrolizumab has demonstrated a high pathological complete response (pCR) rate in patients with cisplatin‐ineligible muscle‐invasive bladder cancer (MIBC). However, whether this therapeutic benefit reflects true pharmacologic synergy or can be explained by inde...
Riko Ikeda, Soichiro Yoshida, Wei Chen et al.· International journal of uro...· 1 citation
Avelumab first‐line maintenance is an established treatment strategy for patients with advanced or metastatic urothelial carcinoma without progression after platinum‐based chemotherapy. Overall survival outcomes reported in international real‐world cohorts are difficult to compare because of differences in patient back...
R. Kasahara, T. Ueki· International journal of uro...· 0 citations
Perioperative immunotherapy has become the standard of care in patients with high‐risk muscle‐invasive urothelial carcinoma (MIUC). This study aimed to clarify oncological outcomes and safety profiles of adjuvant nivolumab therapy in MIUC, focusing on upper tract urothelial carcinoma (UTUC).
Satoshi Katayama, Tatsushi Kawada, K. Mori et al.· International journal of uro...· 1 citation
It is suggested that treatment-emergent skin toxic effects may serve as an early clinical marker of treatment benefit in patients receiving first-line enfortumab vedotin plus pembrolizumab and warrant prospective validation.
Zachariah Thomas, Cindy Y. Jiang, Patrick Speck et al.· JAMA Network Open· 0 citations
Combination therapy with enfortumab vedotin, a Nectin-4-targeted antibody-drug conjugate, and pembrolizumab, an anti-PD1 antibody, recently supplanted platinum-based chemotherapy as standard first-line systemic therapy for patients with muscle-invasive or metastatic urothelial cancer. A composite biomarker integrating...
James A. Rodrigues, H. Al-Ahmadie, D. Aggen et al.· Clinical Cancer Research· 0 citations
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