Transcriptome profiling of cell-free RNAs in prostate cancer patients on active surveillance

Abstract

In this feasibility study, plasma cfRNA transcriptomes from 64 men with prostate cancer on active surveillance revealed differences between stable disease and progression to radical prostatectomy and suggested a predominantly non-tumour origin of circulating RNA. These findings demonstrate the feasibility of cfRNA transcriptomic analysis in this setting and support its further investigation as a minimally invasive adjunct for personalised risk stratification and monitoring.