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Open access Jul 2026

Heterologous Expression of a Neurospora crassa Catalase Reprograms the Cellulase System and Enhances β-Glucosidase Production in Trichoderma reesei

Efficient saccharification of lignocellulose, the most abundant renewable carbon reservoir resource, is of great industrial importance. Trichoderma reesei is a premier cellulase producer, but its fermentation efficiency is often constrained by dual challenges: dissolved oxygen limitation and intrinsic oxidative stress....

Hao-Wen Sun, Chang-Bin Tang, Yifan Chen et al. · 0 citations
Open access Aug 2026

Enhanced Trehalose Production Through Integrated Chassis and Expression Engineering in Bacillus subtilis

Trehalose is a functional disaccharide widely used in the food, pharmaceutical, and cosmetic industries. It is industrially produced via a dual-enzyme process involving maltoligosaccharide trehalose synthase (MTSase) and maltoligosaccharide trehalose hydrolase (MTHase), with Escherichia coli (E. coli) serving as the ex...

Jianghua Chen, Yu-Jue Wang, Qiang Wang et al. · 0 citations
Review Open access Aug 2026

Xylitol Biomanufacturing: Production Technologies, Industrial Applications and Future Opportunities

Xylitol is a five-carbon sugar alcohol widely used in the food, pharmaceutical, oral healthcare, and personal care industries because of its low caloric value, low glycaemic index, and non-cariogenic properties. Industrial production is mainly based on catalytic hydrogenation of xylose, which provides high conversion e...

Yanjie Jia, Wanting Yang, Lulu Zhang et al. · 1 citation
Open access Jul 2026

Scalable catalyst production process for oleate hydratase whole-cell biocatalysis.

The sustainable production of hydroxy fatty acids, such as 10-hydroxystearic acid (10-HSA), by biocatalysis is a promising alternative to petrochemical and castor oil-derived products. However, industrial implementation still requires an efficient and scalable process for biocatalyst production by fermentation, which p...

Rebekka Horstmann, Mario Beckers, J. Viell et al. · 0 citations
Jul 2026

Periplasmic Engineering Enhances Terminal Hydroxylation for Efficient Caffeic Acid Biosynthesis in Escherichia coli.

Caffeic acid (CA) is a valuable phenylpropanoid with applications in food, pharmaceutical, and chemical industries. Microbial production of CA is often limited by the terminal hydroxylation catalyzed by 4-hydroxyphenylacetate 3-monooxygenase (HpaBC). Here, we constructed a de novo CA biosynthetic pathway in Escherichia...

Shangyi Wang, Yuqi Zhuo, Jamila A Tuly et al. · 0 citations

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