Association between postoperative complications and recurrence-free survival in patients with hormone receptor-positive, HER2 negative breast cancer.
Abstract
Background
This study examined the association between 30-day postoperative complications (POC) and recurrence-free survival (RFS) among patients with hormone receptor-positive human epidermal growth factor negative (HR+/HER2-) breast cancer.
Methods
Patients aged ≥ 18 years with stage I-III HR+/HER2- breast cancer were identified from the James Cancer Registry. Recurrence was defined as local, regional, or distant disease after treatment. POC included technical, infectious, respiratory, cardiovascular, and urinary complications. Multivariable regression assessed associations between time-varying postoperative complications and RFS or overall survival (OS).
Results
Among 3022 patients, 103 (3.4%) developed recurrent breast cancer. On univariable analysis, postoperative complications were associated with worse RFS (HR 2.20, 95% CI 1.32-3.68). After adjustment, complications were not associated with RFS (aHR 1.56, 95% CI 0.88-2.74) or OS (aHR 1.00, 95% CI 0.59-1.69).
Conclusion
Among patients with stage I-III HR+/HER2- breast cancer, 30-day postoperative complications were not associated with RFS or OS.