Revisiting Itrifal-e-Aftimoon: A Unani Polyherbal Formulation for Cancer Management and Research

Abstract

Cancer remains a major global health challenge, with conventional therapies limited by toxicity, drug resistance, and accessibility issues. Itrifal Aftimoon, a classical Unani polyherbal formulation from the National Formulary of Unani Medicine, contains twelve botanical and mineral ingredients including Triphala (Terminalia chebula, Emblica officinalis, Terminalia belerica), Plumbago zeylanica, Cuscuta reflexa, and Cassia angustifolia. These herbs provide diverse phytochemicals gallic acid, ellagic acid, plumbagin, flavonoids