factors Nrf2 and NF-κ B contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice

reac-Ufm1 inhibits LPS-induced endothelial cell inflammatory responses through the NF-κ B signaling pathway

CD147 is associated with NF-κB activation during the post-traumatic immune response in a murine trauma model

Extracellular matrix metalloproteinase inducer (CD147) has been proven to play a crucial role in a variety of inflammatory diseases but has not yet been investigated in trauma. The aim of the study was to investigate the role of CD147 in a murine model of trauma and hemorrhagic shock (TH) on the activation of NF-κB, as...

Farrerol alleviates hepatic ischemia-reperfusion injury by regulating the CD14/MyD88/NF-κB signaling pathway.

Hepatic ischemia-reperfusion injury (HIRI) remains a critical complication in liver surgery with limited pharmacological options, and while Farrerol (FA), a natural dihydroflavone, has shown protective effects in other organ IR models, its role in HIRI has never been explored. In this study, we established a murine mod...

TLR3 Overexpression Attenuates D-GalN/LPS-Induced Acute Liver Injury and Is Associated With AMPK Phosphorylation, Autophagy-Related Changes, and IRF3 Upregulation

Background: Toll-like receptor 3 (TLR3) has been implicated in innate immune regulation, but its role in acute liver injury is unknown. The aim of this study was to investigate the functional significance of TLR3 and its underlying mechanisms in D-GalN/lipopolysaccharide (LPS)-induced acute liver injury.Methods: Acute...

HMGB1/MYH9 suppresses PPARγ to induce lung injury in renal ischemia-reperfusion: protective effects of Rosiglitazone.

Modulatory effects of morin on NF-κB/TNF-α and apoptotic signaling against lead-induced hepatotoxicity: an in vivo and in silico study

The global prevalence of lead exposure has escalated, posing significant occupational and ecological health risks. Morin, a naturally occurring flavonoid found in various dietary sources, exhibits notable antioxidant and anti-inflammatory properties. The present study was designed to evaluate the hepatotoxic effects of...