TL;DR
It is suggested that Gomisin A exerts neuroprotective effects against CIRI by enhancing angiogenic activity while attenuating oxidative stress and apoptosis, partly through activation of the VEGF/PI3K/AKT/NOS3 pathway.
BACKGROUND Ischemic stroke remains a major cause of disability and death worldwide, and effective neuroprotective treatments are urgently needed. This study investigated whether Terazosin (TZ), a clinically approved drug with neuroprotective potential, ameliorated Cerebral Ischemia-Reperfusion Injury (CIRI) and explore...
Cerebral ischemia-reperfusion injury (CIRI) worsens outcomes after ischemic stroke, yet effective pharmacological interventions remain limited. Echinocystic acid (EA), a pentacyclic triterpenoid isolated from the fruits of Gleditsia sinensis Lam., has shown neuroprotective activity in CIRI, but its direct molecular tar...
The complexity of the pathological processes of cerebral ischemia-reperfusion injury (CIRI) has far impeded the success of current treatment methods. This study investigated whether gastrodin, the primary bioactive metabolite of Gastrodia elata Blume, alleviates CIRI by modulating brain microvascular endothelial cell (...
Ischemic stroke is an unmet therapeutic need, characterised by excessive oxidative stress, mitochondrial impairment, blood-brain barrier (BBB) damage, and neuronal cell death. 4-Octyl itaconate (4-OI) is known for its promising antioxidant properties; however, its effects in cerebral ischemia/reperfusion (I/R) injury h...
It is demonstrated that kaempferol ameliorates MIRI by activating Nrf2/GPX4-related antioxidant signaling, thereby inhibiting ferroptosis, attenuating apoptosis, reducing myocardial structural damage, and ultimately preserving cardiac function.
IMEG exerts a protective effect against intestinal I/R injury through its antioxidant, anti-inflammatory, and anti-apoptotic properties.
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