Open access
Mosaic KRAS variants in childhood-onset systemic lupus erythematosus
H. Irabu
Madoka Nishimura
Fumiaki Sakura
Takaki Asano
Maho Hatano
Futaba Miyaoka
Shuya Kaneko
Asami Shimbo
Yuko Akutsu
Ryosuke Wakatsuki
Dan Tomomasa
S. Takada
Yuko Hayashi
Satoshi Okada
Masaaki Mori
Tomohiro Morio
Masatoshi Takagi
H. Kanegane
Masaki Shimizu
Medicine
Abstract
This study identifies low-VAF KRAS variants in two children with systemic lupus erythematosus and confirms both variants in independent blood samples. The findings suggest that RAS pathway mosaicism may contribute to childhood lupus beyond classic RAS-associated autoimmune lymphoproliferative disease.