Association between metal co-exposure and frailty: exploring the potential explanatory pathway of inflammation

Frailty, Insulin Resistance, and Stroke Risk: A Prospective Cohort Study and Mendelian Randomization Analysis.

BACKGROUND Stroke is currently the second leading cause of death worldwide, especially among aging populations. Frailty and insulin resistance (IR) have both been associated with stroke risk, but their longitudinal relationship and potential mechanistic links remain unclear. METHODS This prospective study assessed 8,...

Long-term cumulative exposure and change patterns of CTI-FI predict the risk of cardiometabolic multimorbidity in middle-aged and older Chinese adults

Cardiometabolic multimorbidity (CMM) represents an increasing public health concern among aging populations. We aimed to construct and evaluate a multidimensional index integrating inflammation, metabolism, and physiological function–the CTI-FI (C-reactive protein–triglyceride-glucose and frailty index), and examine it...

Association of the combined triglyceride-glucose and frailty index with chronic kidney disease: evidence from two national cohort studies

Relationship Between Cardiometabolic Index and Incident Frailty in Middle-Aged and Older Adults: A Cohort Study

Higher CMI levels were associated with an increased likelihood of developing frailty, and may have potential value as a population-level marker for frailty risk assessment.

Association Between the Dietary Inflammatory Index and Cognitive Frailty in Older Adults: A Cross Sectional Analysis of NHANES Data.

BACKGROUND Cognitive frailty (CF) is a prevalent geriatric syndrome associated with increased risks of falls, hospitalization, disability, and all-cause mortality among older adults. Emerging evidence suggests that chronic inflammation may contribute to the pathophysiology of CF, while dietary patterns can modulate inf...

Inflammation, Metabolic Status and Mental Health as Potential Mediators of the Association Between Socioeconomic Deprivation and Frailty.