The mediating role of inflammation and nutrition metabolism in the methylmalonic acid-stroke association

Understanding regional differences in MASLD: the Indian perspective

Metabolic dysfunction-associated steatotic liver disease (MASLD) in India demonstrates marked regional variation influenced by metabolic risk, lifestyle transition, and population-specific susceptibility. This commentary highlights the growing burden of lean MASLD, the importance of visceral adiposity and cardiometabol...

Bio The silent flame of obesity: inflammation and risk for diabetes

Association of the Endothelial Activation and Stress Index With Cardiovascular Disease Prevalence and Mortality in Individuals With Rheumatoid Arthritis: First Population‐Based Evidence From the National Health and Nutrition Examination Survey

Patients with rheumatoid arthritis (RA) are at increased risk of cardiovascular disease (CVD); however, effective risk stratification tools remain limited. The Endothelial Activation and Stress Index (EASIX) is a composite biomarker reflecting endothelial injury and cellular stress, but its association with CVD in popu...

is associated with higher levels of myeloperoxidase

New ideas about mechanism in APOL1 kidney disease.

Apolipoprotein L1 risk variants contribute to high rates of kidney disease among individuals of African ancestry. These gain-of-function variants cause toxicity to kidney cells, but the mechanism of injury is not clear. Many theories have been proposed, yet the field has not arrived at a consensus. Kim et al. make a co...

Integrating Lipid Metabolomics and Epidemiology: A Mediation Analysis of Blood Lipids between Per- and Polyfluoroalkyl Substances (PFAS) and Renal Impairment.

It is suggested that mixed PFAS exposure, particularly to PFOA and PFHpA, may induce impaired renal function, with increased blood lipids playing an important mediating role.