TL;DR
TmToll-6 could function as a pivotal immune regulator in T. molitor through Toll pathway–dependent AMP regulation in a tissue- and pathogen-specific manner and highlight the evolutionary diversification of Toll receptors in coleopteran immunity.
Innate immunity is the first line of defense against invading pathogens and is essential for maintaining host survival. While the majority of innate immunity studies have focused on pathogen recognition and antimicrobial responses, increasing evidence suggests that lipid metabolism plays a fundamental role in shaping i...
Fas-associated protein with death domain (FADD) is a crucial adaptor protein in the insect Immune Deficiency (IMD) signaling pathway. Although its role in regulating antimicrobial peptide (AMP) synthesis has been established in Drosophila, its function in Ostrinia furnacalis remains unclear. In this study, we identifie...
Probiotics are widely recognized for their ability to promote gut health, modulate immunity, and reduce oxidative stress. As an emerging probiotic within the genus Weissella , Weissella koreensis (WK) exhibits promising immunomodulatory potential. Recent evidence highlights its potential as a functional probiotic...
Paracoccidioidomycosis (PCM) is a neglected tropical disease and the most prevalent systemic mycosis in Latin America. Infection is caused by thermally dimorphic fungi of the genus Paracoccidioides, and disease outcome is largely determined by the nature of the host immune response. Among the pattern recognition recept...
ABSTRACT Enterotoxigenic Escherichia coli (ETEC) remains a leading cause of diarrheal disease in low- and middle-income countries, yet vaccine efforts have struggled to achieve broad and durable protection. To better understand early steps in host-pathogen interactions, we utilized human stem cell-derived jejunal organ...
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