Sep 2026· Human Cell· Vol 39· 0 citations· 88 references
Medicine
TL;DR
The molecular characteristics, expression regulation, and enzymatic and non-enzymatic functions of LOXL4 are summarized, with particular emphasis on the shared mechanisms linking fibrosis and tumor progression, including TGF-β signaling, ECM barrier formation, and immune microenvironment remodeling.
The dynamic interplay between collagen and diverse cell types within the tumor microenvironment (TME) plays a critical role in tumor progression, drug resistance and metastasis. Dysregulated collagen biosynthesis, aberrant post-translational modifications of collagen, and excessive collagen deposition drive extracellul...
Srejani Koley, Debanjana Kundu, Mohan Kumar Durairaj· Journal of Current Oncology· 0 citations
The tumor microenvironment is a complex ecosystem where the extracellular matrix serves as a dynamic signaling hub and regulates tumorigenesis. Thrombospondin-2 (THBS2), a matricellular extracellular matrix protein, has traditionally been regarded as an inhibitor of angiogenesis. However, emerging evidence reveals a pl...
Hetal Abhay Shah, Maushmi S. Kumar· Frontiers in Pharmacology· 0 citations
Chronic liver disease represents a substantial global health burden, yet effective anti-fibrotic therapies remain elusive, largely due to an incomplete understanding of extracellular matrix (ECM) remodeling. While historical research prioritized the role of matrix metalloproteinase (MMP) deficiency in fibrogenesis, cli...
Stephen W. Harris, Purnima Tyagi, R. Huebert· Biomolecules· 0 citations
Extracellular matrix (ECM) stiffness is known to impair T cell function, yet the underpinning molecular cascade remains undefined. This paper investigates the role of lysyl oxidase–like 4 (LOXL4) in ECM stiffening and CD8+ T cell function in lung cancer. Loxl4 knockout and mouse recombinant LOXL4 protein systems, along...
Xu-Yu Gu, Yi-Fei Zhu, Li Xu et al.· Science Advances· 0 citations
