Short-term cortical stimulation combined with targeted rehabilitation and Chondroitinase ABC improves upper limb function following a cervical contusion injury
This study provides robust evidence that short term cortical epidural stimulation as part of a combinational neurorehabilitation paradigm can restore upper limb function after a cervical contusion.
CONTEXT
Complete spinal cord injury (SCI) has traditionally been considered irreversible. However, accumulating evidence suggests that subclinical neural pathways may persist. Multimodal combined neuromodulation targeting brain-spinal-peripheral circuits holds promise to unlock latent neural plasticity, but clinical ev...
Xue Jiang, Li-Xin Zhang, Shu-Xian Li et al.· Journal of Spinal Cord Medic...· 0 citations
BACKGROUND
Spinal cord injury (SCI) interrupts volitional control of lower limbs. Brain-spine interfaces (BSIs), which decode cortical motor intent to trigger epidural electrical stimulation (EES), can provide an artificial pathway linking the brain to spinal motor circuits. Reported benefit, however, has been confined...
Xin-Yu Jiang, Ming-Fang Shi, Jiong-Hui Liu et al.· i Medicina· 0 citations
Background: Recovery after motor complete spinal cord injury (cSCI) remains limited, though spared fibers and latent neural circuits may support neuroplasticity. Transcranial magnetic stimulation (rTMS) and intermittent theta burst stimulation (iTBS) induces LTP like plasticity, however their comparative efficacy in cS...
D. Patel, R. Banerjee, S. Jain et al.· medRxiv· 0 citations
Upper-limb hemiparesis is a prevalent and often refractory sequela of stroke, and conventional rehabilitation approaches often yield limited long-term gains in the chronic phase. Cervical epidural electrical stimulation (EES) has emerged as a promising precision neurorehabilitation strategy to amplify residual corticos...
Ciou-Chan Wu, Hsiang-Ling Huang, Yu-Chen Chen et al.· Frontiers in Behavioral Neur...· 0 citations
CONTEXT
Chronic spinal cord injury (SCI) secondary to spinal tumors may cause persistent motor and sensory dysfunction despite surgical treatment and rehabilitation. Ependymomas are the most common intramedullary spinal tumors in adults, but long-standing neurological deficits after tumor surgery are difficult to treat...
Aslihan Cevik Baran, E. Gonullu, Ece Balkuv et al.· Journal of Spinal Cord Medic...· 0 citations
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