Intraoperative Video-Capillaroscopy of the Vasa Vasorum in Human Superficial Collecting Lymphatic Vessels: Normal Physiology and Association with Lymphedema-Related Structural Deterioration

Abstract

remodeling, and adipocyte hypertrophy. The findings suggest that chronic lymphatic stasis leads to altered tissue remodeling, contributing to epidermal thickening, lymphatic and vascular changes, and adipose tissue hypertrophy. These alterations may impair the regenerative capacity of affected tissues, thereby promoting disease progression. Future work will further elucidate the molecular and immunological mechanisms driving these changes to identify potential therapeutic targets for lymphedema management