TL;DR
Structural change, protein assembly and spatial organization shape immune activation, and how phages employ counter-defense strategies that disrupt these processes are highlighted.
Bacteria employ diverse defense strategies against phage infection, yet mechanisms directly targeting viral proteins remain scarcely documented. In this study, we characterize two bacterial defense systems: TFAD1 featuring a serine protease and TFAD2 featuring a Ser/Thr kinase. We show that TFAD1 and TFAD2 act on pha...
Existing studies in bacteriophage biology have largely examined individual components of the phage life cycle alone. These include lysis mechanisms, depolymerases, and developmental pathways. However, successful phage infection depends on the coordinated progression of interconnected events, from developmental commitme...
Molecular mechanisms of bacterial defense and phage counter-defense are summarized, coevolutionary models are discussed, ecological and applied implications are highlighted, and future research directions are outlined.
Bacteriophages drive pathogen evolution, yet the mechanisms governing phage susceptibility in native bacterial backgrounds, and their consequences within mammalian hosts, remain poorly understood. Here, we mapped >1,000 interactions between 20 diverse Salmonella isolates and 52 wild phages from global disease reservoir...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
