Open access
The Shared IL‐12/IL‐35 p35 Subunit Is Associated With Heightened Atherogenic Risk in African Patients With Type 2 Diabetes
Medicine
Abstract
Interleukin (IL)‐12 and IL‐35 are heterodimeric cytokines that share the p35 subunit and have opposing inflammatory roles. Dysregulated IL‐12/IL‐35 p35 may reflect an imbalance between pro‐ and anti‐inflammatory pathways linking metabolic dysfunction to cardiovascular risk in type 2 diabetes (T2D). However, the clinical significance of circulating IL‐12/IL‐35 p35 levels remains unclear. This study investigated the association between IL‐12/IL‐35 p35 levels and metabolic and atherogenic risk markers in T2D.