Associations of sleep duration, regularity, efficiency, and genetic susceptibility with incident osteoporosis: A prospective UK biobank study.

Objective

To investigate individual and joint associations of objectively measured sleep duration, regularity, efficiency, and genetic susceptibility with osteoporosis risk.

Methods

This prospective cohort study used UK Biobank accelerometer data collected in the United Kingdom during 2013-2015. Cox models assessed associations of sleep duration, regularity, and efficiency with osteoporosis risk. A polygenic risk score was constructed to evaluate the joint association of sleep duration, regularity, efficiency, and genetic susceptibility with osteoporosis risk.

Results

Among 63,083 individuals, 1349 osteoporosis cases occurred during a median 7.8-year follow-up. After adjustment, short sleep duration (hazard ratio [HR] = 1.16, 95% confidence interval [CI]: [1.04, 1.31]), irregular sleep (HR = 1.21, 95% CI: [1.02, 1.43]), and low sleep efficiency (HR = 1.23, 95% CI: [1.08, 1.41]) were associated with increased osteoporosis risk. Furthermore, individuals with high genetic susceptibility and short sleep duration (HR = 1.58, 95% CI: [1.23, 2.03]), irregular sleep (HR = 1.86, 95% CI: [1.25, 2.76]), or low sleep efficiency (HR = 1.57, 95% CI: [1.16, 2.13]) had higher osteoporosis risk than those with low genetic susceptibility and normal sleep duration, regular sleep, or high sleep efficiency, respectively.

Conclusions

Short sleep duration, irregular sleep, and low sleep efficiency were associated with higher osteoporosis risk, including when combined with high genetic susceptibility.