Single-cell transcriptomics of Encephalitozoon intestinalis infection in Caco-2 and Vero cells

Live-cell imaging and ultrastructure expansion microscopy reveal the dynamic intracellular life cycle of the microsporidian parasite Encephalitozoon intestinalis

Campylobacter jejuni Infection Is Associated With Cell-Cycle, Redox, and Metabolic Remodeling of Human Intestinal Epithelial Cells at Single-Cell Resolution

The gene expression signature of multinucleated giant cells in the spleens of Leishmania donovani-infected mice.

Multinucleated giant cells (MGCs) are associated with chronic inflammation and infectious diseases, but their biological characteristics in vivo remain poorly understood because intact cells are difficult to isolate from tissues. In visceral leishmaniasis, heavily parasitized, hemophagocytic MGCs are observed in the sp...

Integrating single-cell RNA sequencing with Visium HD spatial atlas reveals immune–stromal cell interactions in Echinococcus multilocularis metacestode infection

A spatially resolved atlas of immune–stromal interactions in a murine protoscolex‑based hepatic infection model of E. multilocularis is provided, suggesting that myofibroblasts play an important role in fibrotic and immunosuppressive processes.

Chlamydia muridarum TC0066 is required for invasion and intracellular development in tissue culture but dispensable in the murine infection model

Results indicate that TC0066 and C. trachomatis TmeA exhibit conserved functions, but these activities do not translate to detectable, overt changes to in vivo genital-tract pathogenesis, emphasizing the need for care when interpreting outcomes of human chlamydial infection in the murine model.

Tropism of Drosophila innubila Nudivirus in Cell Culture and in Tissues

Most viruses are successful because they can infect and exploit specific host tissues for reproduction and transmission. As a result, we often classify viruses by their ability to infect different tissues: respiratory, reproductive and gut, for example. Thus, knowing the tissue and cellular tropism of a virus may eluci...