Jul 2026· The Egyptian Journal of Internal Medicine· Vol 38· 0 citations· 26 references
TL;DR
The association of IL-38 and its polymorphism with increasing susceptibility to UC was revealed indicating their possible participation in pathogenesis of UC and the possibility of using IL-38 as a new biomarker and UC therapy target.
Abstract
Ulcerative colitis (UC) is a common health issue worldwide. IL-38 is a cytokine that was verified to have anti-inflammatory role and associated with many inflammatory and immune disorders. We attempted to evaluate serum level of IL-38 and its polymorphism (rs7599662) in patients with ulcerative colitis. Seventy-eight patients with UC and 78 healthy subjects were enrolled. Serum concentration of IL-38 was assessed via ELISA technique. Rs7599662 of IL-38 was investigated using RT-PCR. When compared to controls, individuals with UC had considerably higher serum levels of IL-38. Also, the mutant TT genotype of rs7599662 was linked significantly to increased risk of UC (p = 0.009).We revealed the association of IL-38 and its polymorphism with increasing susceptibility to UC indicating their possible participation in pathogenesis of UC and the possibility of using IL-38 as a new biomarker and UC therapy target.
Our study examined the impact of IL6 −174 G/C (rs1800795) and IL18 −607 C/A (rs1946518) promoter polymorphisms on susceptibility to rheumatoid arthritis (RA) and protein/mRNA levels. RA patients had significantly higher serum IL-6 and IL-18 levels than controls; healthy men had higher IL-18 than women (p < 0.001). Conv...
V. Vasileva, G. Vasilev, M. Ivanova et al.· International Journal of Mol...· 0 citations
The immune system and many genes have been linked to bile tract damage in neonatal cholestasis (NC), resulting in liver retention of biliary contents. The most commonly recognized cause of NC is biliary atresia (BA). The study investigated the effect of the IL27 rs181206 polymorphism on NC risk and its potential associ...
A. Elmaghraby, S. Nagi, Amal M. Dawoud et al.· Egyptian Liver Journal· 0 citations
Idiopathic nephrotic syndrome (INS) is the most common chronic glomerular disorder in children and is characterized by a variable response to corticosteroid therapy. Interleukin-38 (IL-38), an anti-inflammatory cytokine, and its gene polymorphisms may influence disease susceptibility and treatment outcomes. This study...
S. Hussein, M. Morsi, O. Abdelaleem et al.· Italian Journal of Pediatric...· 0 citations
Endometriosis is a chronic inflammatory disorder with a complex genetic etiology. The interleukin-17 (IL-17) family, particularly IL-17 A and IL-17 F, plays a critical role in driving pro-inflammatory responses within the peritoneal cavity. This case-control study investigated the association of IL17A rs2275913 and IL1...
D. Jahantigh, M. Taheri, F. Forghani et al.· Bratislava Medical Journal· 0 citations
Asthma is a chronic inflammatory airway disease strongly influenced by genetic factors. Interleukin-33 (IL-33), a key mediator of type 2 immune responses, has been implicated in airway inflammation and remodeling. However, the effects of IL-33 polymorphisms on asthma susceptibility and severity remain unclear, particul...
T. Hsia, Liang-Wen Hang, Te-Chun Shen et al.· Life· 0 citations
Gastric cancer is a multifactorial disease in which Helicobacter pylori (H. pylori) infection plays a central carcinogenic role through inflammation mediated by cytokines, including interleukin-17 (IL-17). The IL-17RA receptor is a key component of this signaling pathway, and genetic polymorphisms in inflammatory genes...
B. Fredi, Mikaela Nagahara, Fabrício Abdalla Brandt et al.· Egyptian Journal of Medical...· 0 citations
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