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A Bioinformatic Approach to Implementing CRISPR Screening Studies in Colorectal Carcinoma

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TL;DR

Two edgeR-based pipelines were constructed that would allow for direct comparison between two genome-wide CRISPR screening datasets of colorectal carcinoma, the Wellcome Sanger Institute’s (Sanger) and the Broad Institute's DepMap (Achilles) datasets, and Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout (MAGeCK) for comparison and validation.

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