Oct 2026· Plant Reproduction· Vol 39· 0 citations· 100 references
Medicine
TL;DR
This review challenges the common assumption that autophagy and proteases form a unified degradative pathway during plant reproduction, showing instead where they act independently, where they converge, and where true molecular coupling remains to be demonstrated, while defining key degradative checkpoints that shape fertility and reproductive resilience.
Autophagy preserves cellular homeostasis through lysosomal degradation, but its machinery also participates in extracellular release. This creates a pharmacological problem: changing autophagy or extracellular vesicle (EV) output can alter intracellular disposal, inflammatory signaling and communication between cells i...
Lin-Lin Deng, Lin-Wei Li, Zhi-Jun Huang et al.· Frontiers in Pharmacology· 0 citations
The molecular basis of lysosomal damage responses, including ATG8ylation, is systematically outlined, and how these networks are implicated in a broad spectrum of pathological conditions such as aging, neurodegeneration, cancer, obesity-related disorders, and immune dysfunction is explored.
S. Minami, Maho Hamasaki· International Review of Cell...· 0 citations
This review provides a detailed overview of seven major evolutionarily conserved selective autophagy pathways: mitophagy, xenophagy, pexophagy, lysophagy, ER-phagy, Golgiphagy, and ribophagy, building on data from four widely used model organisms.
A. Jipa, Virág Vincze, Д. Д. Евдокимова et al.· Autophagy· 0 citations
