TL;DR
EMPA inhibits the progression of AS by activating Pink1/Parkin-mediated mitophagy, thereby improving mitochondrial function and alleviating endothelial injury and providing a novel basis for the cardiovascular protective mechanisms of EMPA.
Findings demonstrate that PTA alleviates AS by suppressing endothelial ferroptosis via the MDM2/GPX4 axis.
Diabetic patients are highly susceptible to vascular calcification, a pathological process lacking specific therapies. Semaglutide, a Glucagon-like peptide-1 receptor agonist (GLP-1RA), provides cardiovascular protection, but its direct effect on diabetic vascular calcification (DVC) and the underlying mechanisms...
BACKGROUND AND AIMS Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 25% of the global population and is a major health concern. Liver sinusoidal endothelial cells (LSECs) undergo morphological and functional alterations during MASLD progression, resulting in endotheliopathy charac...
BACKGROUND Endothelial dysfunction is a critical initiating factor in atherosclerosis (AS), with NPC2 and mTORC1 playing key roles in the regulation of endothelial lipophagy. OBJECTIVE To reveal that hypercholesterolemia disrupts endothelial lipophagy via the mTORC1-NPC2 axis and to explore its role in atheroscleroti...
Rapamycin attenuates ferroptotic and mitochondrial injury, restores macrophage efferocytosis, and reduces atherosclerotic plaque burden, supporting its therapeutic potential in experimental atherosclerosis.
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