Proteomic profiling of cortex and spinal cord in Tau-P301L transgenic cynomolgus macaques
TL;DR
This Data Descriptor provides a reusable non-human primate proteomic resource for tissue-resolved analysis and comparison of tau-associated molecular features.
Abstract
Tau pathology is a defining feature of several neurodegenerative disorders, but reusable proteomic resources from non-human primate tauopathy models remain limited. Here we describe a four-dimensional label-free quantitative proteomic dataset from cortex and spinal cord tissues of wild-type and Tau-P301L transgenic cynomolgus macaques. The dataset comprises 16 neural tissue samples from four wild-type and four Tau-P301L animals, with paired cortical and spinal cord specimens collected from each monkey. Samples were analysed by LC-MS/MS on a Bruker timsTOF Pro platform, and label-free quantification was performed with MaxQuant against a Macaca fascicularis UniProt protein database. In total, 6,632 protein-group entries were identified, of which 6,520 protein groups were retained in the analysis-ready matrix for quality control and reuse. The accompanying records include raw mass spectrometry files, processed expression matrices, sample metadata and analysis scripts. This Data Descriptor provides a reusable non-human primate proteomic resource for tissue-resolved analysis and comparison of tau-associated molecular features.