Gut microbiota disorder aggravates lesions in thioacetamide-induced type A hepatic encephalopathy mice, leading to a decline in the survival curve, accompanied by behavioral, biochemical, and pathological changes, as as decreased Rikenellaceae levels.
Hepatic encephalopathy (HE) is a severe complication of end-stage liver disease that is associated with high mortality; however, its therapeutic options remain limited. The traditional mechanistic understanding focuses on ammonia neurotoxicity, although intestinal bacteria also play a significant role through the gut-l...
Yi-Rui Hu, Ting Wei, Shu-Yan Wang et al.· Current Neuropharmacology· 0 citations
A gut-brain axis mechanism in which sepsis-induced dysbiosis perturbs tryptophan metabolism and AhR signaling, driving a Th17/Treg imbalance that mediates IL-17A/IL-1β-driven hippocampal injury is delineated.
Lei Guan, Meng-Na Yu, Yi-Si Lin et al.· Microbial Pathogenesis· 0 citations
A wide variety of diseases and conditions can affect liver health. Irrigational microbiota and their metabolites are implicated in gut permeability and the development of liver disease, although the exact pathways are still poorly known. Bacterial lipopolysaccharide (LPS) causes changes in Toll‐like receptor signalin...
Reda M. Mansour, Sherif S. Abdel Mageed, Akram N. Salah et al.· Comprehensive Physiology· 0 citations
Introduction Acute-on-chronic liver failure (ACLF) is a life-threatening condition arising from the abrupt worsening of pre-existing chronic liver disease, typically accompanied by multi-organ failure and markedly elevated short-term mortality. Gut microbiota dysbiosis is frequently observed in patients with ACLF, yet...
Zhi-Wu Zeng, Li-Ning Xu, Ming-Qing Yang et al.· Frontiers in Microbiology· 0 citations
Background Sepsis-associated encephalopathy (SAE) is a common complication of sepsis. Its underlying mechanisms remain incompletely understood, and effective treatments are still lacking. Recent studies have shown that the microbiota-gut-brain axis may play a key role in the pathogenesis of SAE, but its potential mecha...
Shan Qi, Ying Yu, Yong-Jie Zhang et al.· Frontiers in Cellular and In...· 0 citations
Background: Hypertension (HT) is a major cardiovascular risk factor, yet traditional models often fail to explain resistant cases. Recent research shifts the focus to the gastrointestinal tract, positioning gut microbiota as a critical modulator of vascular, renal, and neurological functions.
Objective: This study anal...
Ewa Bełc, Rafał Borecki, Julia Kierner et al.· International Journal of Inn...· 0 citations
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