Oct 2026· Medical Oncology· Vol 43· 0 citations· 54 references
Medicine
TL;DR
Overall, this study identifies key molecular determinants of melanoma progression and provides mechanistic evidence explaining carboplatin’s therapeutic activity through modulation of dysregulated transcriptomic hubs and offers a valuable strategy for biomarker discovery and mechanistic evaluation of clinically used agents in melanoma research.
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults, characterized by rapid progression and high resistance to conventional therapies. Recent studies on differential gene expression have contributed to a deeper understanding of the molecular mechanisms underlying its pathogenes...
Luciana Dai Pra Penteado, J. Marcon, Scheila de Avila e Silva· Revista de Estudos Interdisc...· 0 citations
A comprehensive molecular profile of melanomaassociated genes is provided, identifying critical pathways that could serve as potential therapeutic targets and associations with specific metabolites and drug responses offer new avenues for personalized medicine approaches in melanoma treatment.
J. Brahmaiah, U. Adiga, Vijay Kumar et al.· Research journal of biotechn...· 0 citations
Systems-level insight is provided into the molecular architecture of Hodgkin Lymphoma and candidate genes that warrant further experimental investigation are identified, which highlights central regulatory genes involved in HL-associated molecular pathways.
S. Ankitha, Nitya Krishnasamy, S. Selvam et al.· Egyptian Journal of Medical...· 0 citations
This study provides a hypothesis-generating framework for future biomarker-guided combination strategies, which requires validation in HER2-positive cohorts and experimental models.
Feng Wang, N. Mottaghi-Dastjerdi, Fatma Altameemi et al.· Iranian Journal of Basic Med...· 0 citations
The utility of integrating multiomics, pharmacogenomic, structural, and single-cell approaches for therapeutic target discovery and prioritization in cancer is demonstrated.
Dahlak Daniel Solomon, Yung-Kuo Lee, Sachin Kumar et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
By shifting from a "one-target, one-drug" model to a systems-level approach, the proposed MTDL and its natural analogs represent promising candidates for experimental validation in the treatment of complex, obesity-associated CRC.
Merve Uça Apaydın, Huseyin Guner, Resat Unal et al.· Cukurova Medical Journal· 0 citations
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