Skip to content
Log in
Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Precise dual-gene knockout of MSTN and SOCS2 via cytidine base editing enhances muscling and growth in goats

Ling Li Ming-Xing Cao Muhammad Farhab Paing Oo Kyaw Shu Zhao Yi Zhao Fenglei Chen Tariq Sohail Ejaz Ahmad Shao-Xian Cao Yu-Guo Yuan
Aug 2026 · Functional & Integrative Genomics · Vol 26 · 0 citations · 44 references
Medicine

TL;DR

This study successfully established a YE1-AncBE4max-based platform for efficient, precise dual-gene editing in goats and showed that the edited goats exhibited significantly increased body weight and a "double-muscling" phenotype by 90 days of age compared to wild-type controls.

DOI PubMed Semantic Scholar
View source

Similar papers

Open access Jul 2026

Design and transfection of CRISPR/Cas9 constructs for the myostatin gene in Labeo rohita muscle cells

The study successfully established CRISPR/Cas9 plasmid constructs for the mstnb gene in L. rohita and demonstrated their transfection in LRDM cell line across multiple passages, providing a basis for future studies on genome editing approaches using CRISPR/Cas9 constructs in fish muscle cell lines.

Gowhar Iqbal, Nevil Pinto, Darshan Pawaskar et al. · 0 citations
Open access Jul 2026

Production of gene-edited cloned cattle embryos using the CRISPR/EOCas12i system

The feasibility of generating MSTN/BLG double gene-edited cattle embryos using a single CRISPR/EOCas12i plasmid and SCNT is demonstrated, providing a robust platform for multiplex genome editing aimed at improving meat production and milk traits.

Furui Wang, Lei Chen, Yuting Ning et al. · 0 citations
Open access Aug 2026

CRISPR/Cas9‐mediated mstnb1 disruption enhances growth in rainbow trout

The effects of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9‐mediated disruption of the myostatin gene (mstnb1) on the growth performance of rainbow trout (Oncorhynchus mykiss) were evaluated. Two specific guide RNAs (gRNAs) targeting the first exon of the target gene were co‐injected into fer...

A. Bayır, M. Bayır, Wenjing Tao et al. · 0 citations
Open access Aug 2026

Bta-Novel-miR-357 Inhibits the Proliferation and Promotes Apoptosis of Bovine Myoblasts by Targeting S100A2.

Findings reveal a novel epigenetic regulatory axis (novel-miR-357/S100A2 mRNA) involved in early muscle development and provide an important molecular mechanism for deeper understanding of the epigenetic regulatory processes underlying heterosis in cattle.

Gaoqing Xu, Chunqi Hou, He Ding et al. · 0 citations
Aug 2026

CRISPR/Cas9-Mediated Generation and Characterization of an Ent2*/CyO Drosophila melanogaster Strain.

The phenotypic profile of a CRISPR-generated Ent2 mutant line is described and the feasibility of combining genome editing with balancer chromosome strategies in Drosophila is demonstrated, demonstrating the feasibility of combining genome editing with balancer chromosome strategies in Drosophila.

Chikun Li, Lin Li, Ying Chen et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.