Streptococcus thermophilus remodels lipid metabolism to extend healthspan in Caenorhabditis elegans through NHR-49-Delta-9 desaturase axis.

A defined microbial community remodels host metabolism and pathogen resistance in Caenorhabditis elegans

The microbiome is an important regulator of metabolism and health, yet the mechanisms by which microbial communities influence host physiological state remain incompletely understood. Here we used a defined host-microbiota model consisting of Caenorhabditis elegans and an 11-member bacterial consortium representative o...

Yixingensin Extends Lifespan and Modulates Stress-Response and Lipid-Metabolism Programs in Caenorhabditis elegans

Yixingensin (ombuin-3-O-glucoside) is a flavonoid glycoside previously reported to activate peroxisome proliferator-activated receptors in mammalian cells. Whether it affects lifespan in vivo remains unclear. In the present study, the effects of yixingensin were evaluated in wild-type Caenorhabditis elegans using bacte...

Metabolic outsourcing from ingested lactic acid bacteria extends Caenorhabditis elegans healthspan via bacterial amino acid and enzyme provision

RkMsn4, a zinc finger transcription factor, regulates carotenoid and lipid metabolism to enhance tolerance to environmental stress in Rhodosporidium kratochvilovae

ABSTRACT Red yeasts serve as indispensable microbial resources for the production of carotenoids and lipids; however, environmental stress factors often limit their performance during industrial fermentation. The zinc-finger transcription factors Msn2/Msn4 act as central regulators of stress responses in yeasts. Howeve...

Cycloastragenol extends lifespan and enhances stress resistance in Caenorhabditis elegans by inhibiting IIS pathway and activating p38 MAPK-mediated innate immunity.

This study establishes a novel link between CAG-mediated innate immune enhancement and longevity, distinguishing its mode of action from previous telomere-centric models and support its potential development as a safe therapeutic agent for age-related disorders.

Integrated Metabolomic and Proteomic Analyses Reveal Altered Iron Homeostasis and Immunometabolic Remodeling in the Spleen of Solea senegalensis during Vibriosis.

Vibrio anguillarum is a major pathogen impacting Solea senegalensis aquaculture. While host-pathogen competition for iron drives disease progression, the in vivo molecular evidence linking iron homeostasis and immune responses in fish remains limited. Here, we integrated metabolomic and proteomic analyses to characteri...