Open access

Longitudinal associations between neuropsychiatric symptoms, structural and perfusion MRI changes in older adults with Mild Cognitive Impairment

G. Lombardi C. C. Leung R. Burge F. Zelaya S. Bhattacharyya L. Velayudhan

Oct 2026 · medRxiv · 0 citations

Medicine

TL;DR

The findings highlight the importance of identifying NPS in individuals with MCI and the role of structural and perfusion MRI measures as promising biomarkers for monitoring disease progression and improving risk prediction of conversion to dementia.

DOI Semantic Scholar

Read PDF

Similar papers

Open access Sep 2026

Medial Temporal Atrophy and Posterior Cingulate Structural Covariance in Mild Cognitive Impairment.

BACKGROUND Mild cognitive impairment (MCI) is associated with structural abnormalities in regions vulnerable to Alzheimer's disease, but the relative contributions of medial temporal, posterior midline, and association cortices remain unclear. We compared regional gray matter volumes between individuals with MCI and co...

Xiao-Ming Yang, Jian Lyu, Ju-Bo Wang et al. · International Journal of Neu... · 0 citations

Open access Oct 2026

Regional atrophy and hypoperfusion mediate the association between affective symptoms and cognitive impairment in Alzheimer's disease.

OBJECTIVE Affective symptoms are common and associated with poor cognitive outcomes in patients with Alzheimer's disease (AD); however, their underlying neural correlations remain poorly understood. METHODS This study included 105 patients with AD. Patients were classified into an AD with affective symptoms (AD-A) gr...

Jin-Cao Wang, Guan-Qun Zhao, Qing-Zheng Lu et al. · International Psychogeriatri... · 0 citations

Open access Sep 2026

High‐Resolution Diffusion Tensor Imaging of the Hippocampus and Associations With Neuropsychiatric Symptoms in Lewy Body Diseases

Lower hippocampal fractional anisotropy in the LBD spectrum relative to HC potentially reflects microstructure alterations; however, higher hippocampal FA in LBD with more severe depression suggests more complex microstructural changes such as altered synaptic density, Lewy neurite organization, or neuroplastic changes...

Alexandra S. Budd, K. Solar, Myrlene Gee et al. · Hippocampus · 0 citations

Open access Sep 2026

Cross-sectional relationships between memory scores and neurodegeneration biomarkers in patients with suspected cognitive impairment.

INTRODUCTION We aimed to examine whether additional metrics derived from the CERAD Word List Memory Test (WLMT) such as acquisition patterns, error frequencies, and consolidation efficiency, are associated with cerebrospinal fluid (CSF) biomarkers of amyloid and tau pathology, as well as magnetic resonance imaging (MRI...

Lynn Sahhar, Milena Albrecht, Jennifer Pahl et al. · Journal of Clinical and Expe... · 0 citations

Sep 2026

Comparison of baseline characteristics between cognitively normal and mild cognitive impairment and association of white matter hyperintensity trajectories with diagnostic outcomes, cognition, and amyloid-β protein: A longitudinal study

WMH baseline and trajectory changes are key risk factors for CN cognitive decline and WMH trajectory changes are linked to cognitive function and brain Aβ deposition.

W. Ba, Cui-Ping Bao, Ying-Xun Gong et al. · Journal of Alzheimer's Disea... · 0 citations

Open access Sep 2026

Hippocampal subfield diffusion abnormalities in Parkinson’s disease with mild cognitive impairment: a volumetric and diffusion MRI study

PD-MCI was characterized by distributed hippocampal diffusivity alterations despite the absence of detectable volumetric differences, and subfield-specific diffusion measures may provide complementary information on cognition-related hippocampal involvement beyond conventional volumetry.

Yu-Mei Chen, Lu Peng, Qing Hu et al. · Frontiers in Aging Neuroscie... · 0 citations