TL;DR
Cannabinoid-based therapies do not improve agitation, neuropsychiatric symptoms, or cognition in Alzheimer’s disease and increase somnolence.
AAT was associated with reduced overall BPSD severity, although this effect was sensitive to study quality and was not retained after excluding high-risk studies, and confidence is limited by methodological heterogeneity and the predominance of studies at moderate to serious risk of bias.
Background Non-pharmacological interventions are increasingly used as complementary strategies for Alzheimer's disease (AD), yet their comparative effects on cognitive outcomes remain insufficiently defined. Objective To compare and rank the cognitive effects of different non-pharmacological interventions in patients w...
ABSTRACT. Parkinson’s disease (PD) involves significant non-motor symptoms (NMS) linked to glutamate dysregulation. Objective: This review evaluates the efficacy of N-methyl-D-aspartate (NMDA) receptor antagonists (memantine and amantadine) for treating NMS. Methods: A search was conducted in the databases PubMed and C...
Background Migraine is frequently comorbid with depression and anxiety, conditions that amplify disease burden and may impair preventive treatment response. Calcitonin gene-related peptide (CGRP)-targeted therapies have demonstrated robust efficacy in reducing migraine frequency, with emerging evidence suggesting concu...
OBJECTIVE Antipsychotics are first-line treatments for schizophrenia and related psychotic disorders but are frequently accompanied by cardiometabolic adverse effects (weight gain, hypertension, dyslipidaemia, hyperglycaemia). We assessed whether supervised exercise interventions enhance psychopathology outcomes and re...
INTRODUCTION Low back pain, migraine, and other headache disorders are major contributors to disability, and interest in cannabinoid-based interventions has increased despite uncertainty regarding their indication-specific therapeutic value. This systematic review evaluated the efficacy and safety of isolated cannabino...
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