Transposable elements, immune-related genes and epigenetic context in teleost fish: insights from a systematic review and in silico analysis.

Cis-regulatory co-option of a transposon family reinforces cell identity across the immune system.

Transposable elements (TEs) comprise about half of the human and mouse genomes and contribute to gene regulation during immune responses. However, how TEs acquire cis-regulatory functions during immune cell development remains poorly understood. Here, we analyzed hundreds of datasets profiling chromatin accessibility,...

The Transposon Toolkit for Immune Isoform Diversity in Evolution and Disease

Transposable elements (TEs) occupy roughly half of the genomic content across mammals and have long been recognized for their contributions to immune gene regulation as co-opted enhancers and promoters. Less appreciated is their role in diversifying the immune transcriptome itself. TE sequences embedded in introns and...

Transposable elements: Drivers of regulatory innovation and adaptation in plants.

Transposable elements (TEs) constitute a major fraction of eukaryotic genomes and represent one of the most abundant classes of repetitive sequences in plants. Recent advances in sequencing technologies, together with the increasing availability of telomere-to-telomere and pan-genome assemblies, have enabled comprehens...

Telomere-to-telomere co-mapping of transposable elements and human genes identifies a cluster of young L1 elements in the interferon-alpha domain with potential evolutionary arms-race.

Transposable elements (TEs) have played a central role in major evolutionary transitions across the human lineage, from eukaryogenesis to the emergence of the eutherian placenta, and are currently reactivated in cancer and autoimmune diseases. The complete telomere-to-telomere (T2T) assembly enables comprehensive inves...

Transcriptional reprogramming and epigenetic regulation in Paramecium caudatum: a new model for studying extreme germline DNA elimination.

Metazoans suppress transposons via small RNA-mediated silencing mechanisms, whereas ciliates have evolved a unique repressed strategy by physically eliminating transposons during somatic macronuclear genome development, offering unique models for transposon regulation and programmed DNA rearrangement. The ciliate Param...

Transposable Elements Profiling Reveals DUXA-associated MLT1D Endogenous Retroviral Elements Activation During Bovine Maternal to Zygotic Transition