Quantitative assessment of systolic and diastolic left ventricular energy loss using vector flow mapping in healthy participants: a retrospective observational study

Left Ventricular Longitudinal Strain Is Associated with Ascending Aortic Diameters in Healthy Adults—A Detailed Single-Center Retrospective Analysis from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Healthy Study

Even in the absence of cardiovascular pathology, a finely tuned interaction can be observed between regional LV deformation, especially with LV-LS and the size of the ascending aorta in healthy individuals.

First-Phase Ejection Fraction: A Novel Approach to Detecting Early Systolic Dysfunction in Hypertrophic Cardiomyopathy.

Given its high sensitivity in evaluating left ventricular systolic function in patients with HCM, EF1 represents a promising adjunctive parameter for the multimodal assessment of systolic function in this population.

Quantitative MRI assessment of left ventricular filling: associations with left atrial and pulmonary artery dimensions in a population-based study

In individuals free of overt cardiovascular disease, MRI-derived LV filling dynamics were associated with structural alterations of the left atrium and pulmonary vasculature, suggesting that changes across the cardiopulmonary axis may already be detectable by whole-body MRI before clinical disease becomes apparent.

Left ventricular systolic dysfunction detected by speckle tracking in hypertensive patients with preserved ejection fraction (cid:2)

Peak filling rate assessed by myocardial perfusion imaging predicts adverse outcomes in women with chronic coronary syndromes

Background Diastolic dysfunction may represent an important risk dimension beyond myocardial ischemia and systolic impairment, particularly in women with chronic coronary syndromes (CCS). However, the prognostic value of myocardial perfusion imaging (MPI)-derived diastolic parameters and their potential sex-specific differences remain uncertain. Therefore, this study aimed to evaluate the prognostic significance of single photon emission computed tomography (SPECT) MPI-derived diastolic parameters in patients with CCS without reduced ejection fraction (EF <40%). Methods In this retrospective cohort study, data of 1,446 patients undergoing resting MPI were analyzed at the First Hospital of Shanxi Medical University [2016–2021]. The diastolic parameters obtained from MPI included peak filling rate (PFR), mean filling rate over the first third of the end-systole to end-diastole phase (MFR/3), and time to peak filling from end-systole (TTPF). Propensity score matching balanced baseline clinical characteristics between sexes. Multivariable Cox regression evaluated the associations between sex, diastolic parameters, and major adverse cardiovascular events (MACEs). These analyses were further differentiated by total perfusion deficit (TPD) ≥10% and EF ≥50% groups. Results (I) Over a median 3.05-year follow-up, 519 patients (35.9%) experienced MACE. (II) No statistically significant differences were observed in the predictive value for MACE among PFR, MFR/3, TTPF, and the combination of these three parameters (P=0.956). (III) Reduced PFR independently predicted MACE in women [hazard ratio (HR) 0.61, P=0.028] but not in men (P=0.167). This sex difference persisted in patients with TPD ≥10% (HR 0.36) and EF ≥50% groups (HR 0.57, all P<0.05). Conclusions In patients of CCS without reduced EF, MPI-derived PFR demonstrates sex-specific prognostic value, serving as an independent predictor of MACE in women but not men. These findings highlight the potential of diastolic analysis to refine risk stratification in women.

Prognostic Value of Cardiac MRI-derived Left-to-Right Global Longitudinal Strain Ratio in ST-Elevation Myocardial Infarction.

Purpose To investigate the association between biventricular imbalance, as reflected by the left ventricular (LV) and right ventricular (RV) global longitudinal strain (GLS) ratio derived from cardiac MRI feature tracking, and all-cause death in isolated left ventricular myocardial infarction. Materials and Methods In this multicenter retrospective study, the primary end point was all-cause mortality. The GLS ratio was defined as the ratio of LVGLS and RVGLS. Long-axis (two, three, and four chambers) and short-axis cine sequences were used for strain analysis. Kaplan-Meier curves, Cox proportional hazards regression, and the C statistic were used for statistical analysis. Results In the internal testing set (919 patients; median age, 59 years [IQR, 51-66 years]; 769 [83.7%] male), 90 (9.8%) patients died over a median follow-up period of 60.9 months (IQR, 47.7-83.6 months). The GLS ratio was the strongest independent predictor for all-cause death (adjusted hazard ratio [HR], 1.69; 95% CI: 1.45, 1.97; P < .001). The model, along with clinical conventional imaging, RVGLS, and GLS ratio, demonstrated improved discrimination (C statistic, 0.82; 95% CI: 0.76, 0.87) and calibration (χ2, 71.88). A GLS ratio of more than 0.95 was responsible for a fourfold death risk after multivariable adjustment. In those with normal RVGLS (HR, 2.43; 95% CI: 1.15, 5.10; P = .02), reserved LVGLS (HR, 5.38; 95% CI: 2.46, 11.79; P < .001), and both (HR, 7.76; 95% CI: 2.16, 11.90; P = .002), a high GLS ratio (>0.95) still predicted all-cause death. Conclusion In isolated LV myocardial infarction, an elevated GLS ratio may provide additional prognostic information for all-cause death. Keywords: Left Ventricular Myocardial Infarction, Ventricular Imbalance, Global Longitudinal Strain, Cardiac MRI, Feature Tracking Supplemental material is available for this article. © RSNA, 2026.