Sep 2026· Actas Dermo-Sifiliográficas· pp.
104725
· 0 citations
Medicine
TL;DR
PCL generally has a favorable prognosis, although the high proportion of late recurrences reinforces the need for close and prolonged clinical follow-up.
Abstract
Background
Primary cutaneous leiomyosarcoma (PCL) is a rare tumor of smooth muscle origin.
Methods
We analyzed 39 cases of PCL diagnosed between 1998 and 2023 at 5 hospitals in Madrid, Spain.
Results
The median age was 79 years, with a predominance of men (68%) and preferential involvement of the scalp (36%). Overall, 92% of tumors were T1 (<5 cm), and 62% showed predominantly dermal involvement on histopathology. The local recurrence rate was 18%, regardless of depth of invasion. Local recurrence was less frequent after Mohs surgery (12%) than after conventional surgery (28% with 1-cm margins and 16% with margins >1 cm). Three patients (8%) developed metastases, with only 1 tumor-related death. The 5-year disease-free survival rate was 80%.
Conclusions
PCL generally has a favorable prognosis, although the high proportion of late recurrences reinforces the need for close and prolonged clinical follow-up.
BACKGROUND
Primary breast angiosarcoma (PBA) is rare, and limited data exist because studies often combine primary and secondary angiosarcoma patients.
METHODS
For patients with PBA who received care at a comprehensive cancer center from 1991 to 2025 and underwent surgical resection, this retrospective study collecte...
Rick D. Vavolizza, A. Subramaniam, Min Yi et al.· Annals of Surgical Oncology· 0 citations
BACKGROUND
Aggressive angiomyxoma (AA) is a rare, locally infiltrative mesenchymal tumor with frequent local recurrence. Optimal management remains poorly defined, particularly the roles of surgery, endocrine therapy, and observation.
METHODS
We retrospectively analyzed patients with histologically confirmed AA treat...
O. Babatunde, K. Seier, R. Desir-Camille et al.· European Journal of Cancer· 0 citations
Background: Malignant Fibrous Histiocytoma (MFH), reclassified as undifferentiated pleomorphic sarcoma (UPS) in the 2013 World Health Organization (WHO) classification, is a high-grade pleomorphic sarcoma of mesenchymal origin. It is the most common soft-tissue sarcoma in late adulthood, predominantly affecting males a...
Mohamed Ali Bekir, Batuhan Ayhan· Archives of Current Medical...· 0 citations
Background: Leiomyosarcoma (LMS) is a rare aggressive sarcoma with substantial heterogeneity in anatomical presentation, stage, treatment, and survival. We evaluated clinical characteristics, treatment patterns, and survival, with particular emphasis on whether anatomical site independently predicted overall survival (...
R. Pinninti, K. Subramaniyan, R. Iyer et al.· Journal of Clinical Medicine· 0 citations
Inflammatory rhabdomyoblastic tumor (IRMT) is a newly defined subtype of skeletal muscle neoplasm with uncertain malignant potential. Herein, we present a series of 22 IRMT cases to further expand its clinical and pathologic spectrum. This cohort enrolled 20 males and 2 females, with a median age of 42 years (range: 18...
Ying-Yu Yang, Jun-Qing Yuan, P. Zhu et al.· Applied immunohistochemistry...· 0 citations
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