Aug 2026· European Journal of Clinical Pharmacology· Vol 82· 0 citations· 109 references
Medicine
TL;DR
A systematic narrative review of drug-induced ECG changes, QTc measurement methodology, TdP risk stratification, and ECG monitoring protocols covering January 2006 to April 2026 found evidence that evidence-based monitoring protocols, correction of modifiable risk factors, and prompt recognition of ominous ECG patterns substantially reduce adverse outcomes.
The concomitant use of ceftriaxone and proton pump inhibitors (PPIs) is common in hospital practice. However, it is unclear whether individual PPIs differ in their effects on QT interval prolongation, ventricular arrhythmia, or cardiac arrest, collectively termed as QVC events. We conducted a two-stage, real-world stud...
Ye-Chao Chen, Qiao-Ling Gu, Ming Zhao et al.· Cardiovascular Toxicology· 0 citations
OBJECTIVES
To systematically evaluate the incidence and prevalence of drug-induced QT interval prolongation and torsades de pointes (TdP) among adults exposed to QT-prolonging medications.
DESIGN
Systematic review of observational and interventional studies identified through MEDLINE (via PubMed).
SETTING
Primary a...
Dragos-Paul Hagiu, Lina Hamdi, Edouard Ollier et al.· Journal of Psychiatric Pract...· 0 citations
We aimed to investigate the prevalence of QTc interval prolongation (QTcIP), QTc-prolonging drug exposure, and associated clinical and genetic risk factors in adult patients hospitalized in the Coronary Intensive Care Unit. This observational cohort study included 207 patients hospitalized for ≥24 h. Clinical, laborato...
Gozde Akturk, A. A. Başkurt, A. Çağlayan et al.· Canadian Journal of Physiolo...· 0 citations
BACKGROUND AND AIMS
Nausea and vomiting accompany pregnancy, gastroenteritis, migraine, the perioperative period, and cytotoxic chemotherapy, and antiemetics are among the most frequently prescribed drugs worldwide. Several antiemetic classes delay ventricular repolarization and prolong the QT interval, a substrate for...
A. Moustafa, Omar Dabash, P. Panigrahi et al.· European Heart Journal - Car...· 0 citations
Congenital long QT syndrome (LQTS), the first identified cardiac ion channelopathy, is characterized by delayed ventricular repolarization and a prolonged heart rate-corrected QT interval (QTc), conferring an increased risk of malignant ventricular arrhythmias and sudden cardiac death. Current standard-of-care manageme...
Qing Liu, Yi-Fei Wang, Ping Zhang et al.· Reviews in cardiovascular me...· 0 citations
Background: Fragmented QRS (fQRS) is characterized by morphological irregularities in ventricular depolarization on a standard 12-lead surface electrocardiogram (ECG) and is considered a non-invasive indicator of myocardial conduction heterogeneity. Microstructural changes such as non-uniform anisotropy, gap junction r...
S. Koroglu, E. Aksu, Ekrem Gemci· Cukurova Anestezi ve Cerrahi...· 0 citations
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