Jan 2026· The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale· Vol 2026· 0 citations· 64 references
Medicine
TL;DR
This review explores the diagnostic and therapeutic potential of EBV‐derived exosomes and highlights their challenges due to the lack of standardization and difficulties in exosome isolation and improving exosome‐based therapy efficiencies.
Abstract
Epstein–Barr virus (EBV), a member of the herpesvirus family, is extremely prevalent worldwide. EBV is a double‐stranded DNA virus associated with various malignancies, autoimmune diseases, and lymphomas. Transmission occurs through different means, including saliva and organ transplantation. EBV can produce and secrete vesicles that are critical in intracellular communication and valuable biomarkers in body fluids to diagnose potential diseases. They can also be utilized in targeted therapy. Exosomes are extracellular vesicles (EVs) that play a significant role in several biological processes. Some important components in EBV‐related EVs can be valuable biomarkers, including proteins such as latent membrane protein 1 (LMP1) and LMP2A, microRNAs (miRNAs), and long noncoding RNAs (lncRNAs). This review explores the diagnostic and therapeutic potential of EBV‐derived exosomes. It also highlights their challenges due to the lack of standardization and difficulties in exosome isolation and improving exosome‐based therapy efficiencies.
Exosomes are nanoscale, double-membrane extracellular vesicles of endocytic origin that are released by diverse cell types under both physiological and pathological conditions. They have emerged as critical mediators of intercellular communication and immune regulation during homeostasis and infection. Accumulating evi...
Overall, current evidence supports exosome-mediated communication as a biologically relevant mechanism across reproductive physiology, infertility-related disorders, and HPV-associated disease, while further standardized and clinically validated studies are required to establish their diagnostic and therapeutic utility...
Serafoula-Natalia Siourtou, S. Stavros, M. Daskalaki et al.· Current Issues in Molecular...· 0 citations
Epstein–Barr virus (EBV) is an oncogenic human gammaherpesvirus that is prevalent worldwide. Although over 95% of the world’s population harbors this pathogen, the vast majority of infections are asymptomatic, largely due to immune system involvement. However, in certain situations, such as when individuals are immunoc...
The Epstein–Barr virus (EBV) belongs to the gamma subgroup of human herpesviruses. EBV is particularly lymphotropic regarding its latency, meaning that it preferentially targets lymphocytes as its immunological niche. During the establishment of the complex virus–host relationships, the virus influences the human host...
L. Wallot, T. Hohmann, Urszula Hohmann et al.· Cell Biochemistry and Functi...· 0 citations
Dengue virus (DENV) is a major global health concern, with millions of cases reported each year, particularly in tropical and subtropical regions. Aedes aegypti and Aedes albopictus, are the primary vectors of the virus responsible for the transmission of infection. Clinical consequences of Dengue infection range from...
Ravi Kant, Anushka Singh, N. Ganguly et al.· Microbial Pathogenesis· 0 citations
While typically associated with benign infectious mononucleosis, Epstein–Barr virus (EBV) is now recognized as a pivotal driver of complex immunopathological disorders. By shuttling between lytic replication and strategic latency programs, EBV reprograms B-cell biology to evade immune surveillance and disrupt homeostas...
Evelyn Van de Perre, B. Van Nieuwenhuyse, J. Yombi· Viruses· 0 citations
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