Aug 2026· Nan fang yi ke da xue xue bao = Journal of Southern Medical University· Vol 46 8, pp.
1915-1925
· 0 citations
Medicine
TL;DR
PPT1 overexpression promotes GC progression by activating the ERK signaling pathway and thereby modulating lipid metabolism, suggesting its potential as a novel prognostic biomarker and a therapeutic target for GC.
Background Abnormal lipid metabolism promotes lung cancer progression. This study explores how TGFBR3 regulates fatty-acid-metabolism-related protein expression via the FATP2-ACSL1 axis to suppress lung cancer invasion and metastasis, and preliminarily assesses the potential clinical value of TGFBR3 and FATP2. Methods...
Tian Luo, Yuanyuan Wu, Nuoya Ma et al.· Frontiers in Oncology· 0 citations
Abstract: Background: Dysregulated expression of prolyl 4-hydroxylase subunit alpha 3 (P4HA3) has been identified in Colon cancer, breast cancer, head and neck cancers, etc. and is closely associated with tumor progression. However, its specific roles in gastric cancer (GC), particularly regarding alterations in metabo...
Tao Wang· Pakistan Journal of Pharmace...· 0 citations
Background Palmitoylation and dysregulated fatty acid metabolism are key components of tumor metabolic reprogramming and play important roles in the initiation, progression, and immune regulation of breast cancer (BRCA). However, their systemic molecular characteristics and clinical predictive value remain incompletely...
Zhun Zhang, Ying Fu, Yusong Zhou et al.· Frontiers in Pharmacology· 0 citations
Bioinformatics analyses suggest that EPHX2 may participate in metabolic and tumor progression-related regulatory networks and may serve as a prognostic biomarker in LUAD.
Background: Fascin actin-bundling protein 1 (FSCN1) modulates the expression of key lipogenic enzymes fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD1) in colorectal cancer (CRC), but the underlying mechanisms remain elusive. Methods: Bioinformatics analyses were performed to evaluate FSCN1 expression and i...
Objective Despite advances in treatment, small cell lung cancer (SCLC) remains highly aggressive and prone to relapse, leading to poor patient outcomes. Histone HIST1H4L is a key protein that maintains chromatin structure, but its role in SCLC is still unclear. This study aims to define its oncogenic role in SCLC and t...
Shi-Cheng Feng, Min Feng, Zhi-Qiang Lu et al.· Frontiers in Oncology· 0 citations
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